TY - JOUR
T1 - RAP a novel type of ER chaperone
AU - Bu, Guojun
AU - Schwartz, Alan L.
N1 - Funding Information:
We thank Stuart Kornfeld and Philip Stahl for helpful discussion and reading of the manuscript. Research in the authors' laboratories is supported by grants from NIH, American Cancer Society, Alzheimer's Association and Monsanto.
PY - 1998/12/1
Y1 - 1998/12/1
N2 - Members of the low-density lipoprotein (LDL) receptor gene family play an important role in cellular uptake of various extracellular ligands. Recent studies have shown that a 39-kDa protein known as RAP (receptor-associated protein) serves as a molecular chaperone to assist the folding of certain LDL-receptor family proteins and their passage through the secretory pathway. In this review, the authors discuss our current understanding of the roles of RAP as a molecular chaperone/escort protein and present a model of how RAP might carry out these functions.
AB - Members of the low-density lipoprotein (LDL) receptor gene family play an important role in cellular uptake of various extracellular ligands. Recent studies have shown that a 39-kDa protein known as RAP (receptor-associated protein) serves as a molecular chaperone to assist the folding of certain LDL-receptor family proteins and their passage through the secretory pathway. In this review, the authors discuss our current understanding of the roles of RAP as a molecular chaperone/escort protein and present a model of how RAP might carry out these functions.
UR - http://www.scopus.com/inward/record.url?scp=0032404537&partnerID=8YFLogxK
U2 - 10.1016/S0962-8924(98)01283-5
DO - 10.1016/S0962-8924(98)01283-5
M3 - Review article
C2 - 9714598
AN - SCOPUS:0032404537
SN - 0962-8924
VL - 8
SP - 272
EP - 276
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 7
ER -