Randomized Secondary Prevention Trials in Participants with Symptomatic Intracranial Atherosclerotic Stenosis

Lauren E. Dunn, Yan Wang, Tareq Kass-Hout, David Chiu

Research output: Contribution to journalReview articlepeer-review

Abstract

Intracranial atherosclerotic stenosis is a prevalent cause of ischemic stroke worldwide. Its association with silent cerebral infarcts and its contribution to cognitive impairment and dementia emphasize the critical need for disease prevention and effective management strategies. Despite extensive research on secondary stroke prevention treatment over the past several decades, intracranial atherosclerotic stenosis continues to exhibit a notably higher recurrent stroke rate compared with other causes. This review focuses on randomized secondary prevention trials involving antithrombotic therapy, endovascular treatment, open surgical therapy, and remote ischemic conditioning. It aims to provide an insightful overview of the major findings from each trial and their implications for future research efforts.

Original languageEnglish
Pages (from-to)324-334
Number of pages11
JournalStroke
Volume55
Issue number2
DOIs
StatePublished - Feb 1 2024

Keywords

  • antithrombotic agents
  • cerebral infarction
  • endovascular procedures
  • intracranial arteriosclerosis
  • secondary prevention

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