@article{721534025b9549148c13b91f574e1814,
title = "Randomized Controlled Trial of Home-Based Lifestyle Therapy on Postpartum Weight in Underserved Women with Overweight or Obesity",
abstract = " Objective: This study aimed to assess the efficacy of a home-based lifestyle intervention delivered through Parents as Teachers (PAT), a national home-visiting organization, designed to minimize excessive weight gain through 12 months post partum in socioeconomically disadvantaged (SED) African American women with overweight or obesity. Methods: This randomized controlled trial was conducted at a single center as part of the Lifestyle Interventions for Expectant Moms (LIFE-Moms) consortium. Analysis was conducted with 185 SED African American women (BMI 25.0-45.0 kg/m 2 at pregnancy onset) retained from an original sample of 267 randomized to standard PAT or PAT+Lifestyle, which embedded lifestyle therapy within standard PAT delivered prenatally and for 12 months post partum. Results: Compared with standard PAT, the PAT+Lifestyle group gained less weight (2.5 kg vs. 5.7 kg; P = 0.01) and were more likely to return to their baseline weight (38.0% vs. 21.5%; P = 0.01) from baseline to 12 months post partum. There were no differences between groups in cardiometabolic outcomes, indices of glycemic control and insulin sensitivity, and plasma lipid profile. The estimated cost of PAT+Lifestyle was $81 more to deliver per family than standard PAT. Conclusions: PAT+Lifestyle decreases weight gain during pregnancy through 12 months post partum in SED African American women with overweight or obesity at the start of pregnancy with minimal additional cost. ",
author = "Debra Haire-Joshu and Cahill, {Alison G.} and Stein, {Richard I.} and {Todd Cade}, W. and Woolfolk, {Candice L.} and Kelle Moley and Amit Mathur and Schwarz, {Cynthia D.} and Schechtman, {Kenneth B.} and Samuel Klein",
note = "Funding Information: Funding agencies: This study was supported by the National Institutes of Health grants DK94416, DK56341 (Nutrition Obesity Research Center), DK092950 (Center for Diabetes Translation Research), DK20579 (Diabetes Research Center), and RR024992 (Clinical and Translational Science Award). Lifestyle Interventions for Expectant Moms (LIFE-Moms) is supported by the National Institutes of Health through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK, U01 DK094418, U01 DK094463, U01 DK094416, 5U01 DK094466 [Research Coordinating Unit]), the National Heart, Lung, and Blood Institute (NHLBI, U01 HL114344, U01 HL114377), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD, U01 HD072834), the National Center for Complementary and Integrative Health (NCCIH), the NIH Office of Research on Women{\textquoteright}s Health (ORWH), the Office of Behavioral and Social Sciences Research (OBSSR), the Indian Health Service, and the Intramural Research Program of the NIDDK. We thank the LIFE-Moms consortium members for their contributions to the development and oversight of the common measures and procedures shared across the trials. Disclosure: The authors declared no conflict of interest. Author contributions: DHJ, SK, AGC, WTC, RIS, AM, KM: study concept and design. DHJ, AGC, WTC, CDS, RIS, AM, SK, KM: data collection. DHJ, SK, KBS, CLW: analysis and interpretation of data. DHJ, SK, WTC, RIS, CLW, AM, AGC, KM: drafting of manuscript. DHJ, SK, WTC, CDS, RIS, CLW, AM, AGC, KM: critical revision of the manuscript. DHJ, SK, AGC: obtain funding. Clinical trial registration: ClinicalTrials.gov identifier NCT01768793. Received: 20 July 2018; Accepted: 21 November 2018; Published online 22 March 2019. doi:10.1002/oby.22413 Funding Information: agencies: This study was supported by the National Institutes of Health grants DK94416, DK56341 (Nutrition Obesity Research Center), DK092950 (Center for Diabetes Translation Research), DK20579 (Diabetes Research Center), and RR024992 (Clinical and Translational Science Award). Lifestyle Interventions for Expectant Moms (LIFE-Moms) is supported by the National Institutes of Health through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK, U01 DK094418, U01 DK094463, U01 DK094416, 5U01 DK094466 [Research Coordinating Unit]), the National Heart, Lung, and Blood Institute (NHLBI, U01 HL114344, U01 HL114377), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD, U01 HD072834), the National Center for Complementary and Integrative Health (NCCIH), the NIH Office of Research on Women{\textquoteright}s Health (ORWH), the Office of Behavioral and Social Sciences Research (OBSSR), the Indian Health Service, and the Intramural Research Program of the NIDDK. We thank the LIFE-Moms consortium members for their contributions to the development and oversight of the common measures and procedures shared across the trials.The authors thank the study subjects for their participation, the study staff for their help in conducting this study, and the LIFE-Moms consortium members for their contributions to the development and oversight of the common measures and procedures shared across the trials. All data generated from this project will be administered in accordance with both University and NIH policies, including the most current NIH data release and resource sharing policy. The results from this work will be presented at scientific meetings, published in scientific journals, and made freely available to the public according to NIH guidelines. Publisher Copyright: {\textcopyright} 2019 The Obesity Society",
year = "2019",
month = apr,
doi = "10.1002/oby.22413",
language = "English",
volume = "27",
pages = "535--541",
journal = "Obesity",
issn = "1930-7381",
number = "4",
}