Raman spectroscopy provides a noninvasive approach for determining biochemical composition of the pregnant cervix in vivo

Christine M. O'Brien, Elizabeth Vargis, Bibhash C. Paria, Kelly A. Bennett, Anita Mahadevan-Jansen, Jeff Reese

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

The molecular changes that occur with cervical remodelling during pregnancy are not completely understood. This study reviews Raman spectroscopy, an optical technique for detecting changes in the pregnant cervix, and reports preliminary studies on cervical remodelling in mice that suggest that the technique provides advantages over other methods. Conclusion Raman spectroscopy is sensitive to biochemical changes in the pregnant cervix and has high potential as a tool for detecting premature cervical remodelling in pregnant women.

Original languageEnglish
Pages (from-to)715-721
Number of pages7
JournalActa Paediatrica, International Journal of Paediatrics
Volume103
Issue number7
DOIs
StatePublished - Jul 2014

Keywords

  • Cervical remodelling
  • Cervix
  • Parturition
  • Pregnancy
  • Preterm birth

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