Rafts defined: A report on the Keystone symposium on lipid rafts and cell function

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Abstract

The recent Keystone Symposium on Lipid Rafts and Cell Function (March 23-28, 2006 in Steamboat Springs, CO) brought together biophysicists, biochemists, and cell biologists to discuss the structure and function of lipid rafts. What emerged from the meeting was a consensus definition of a membrane raft: "Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and proteinlipid interactions." This definition helps to clarify current thinking in a field that has been plagued by the heterogeneous and sometimes ephemeral nature of its subject.

Original languageEnglish
Pages (from-to)1597-1598
Number of pages2
JournalJournal of lipid research
Volume47
Issue number7
DOIs
StatePublished - 2006

Keywords

  • Cholesterol
  • Membrane microdomains
  • Sphingolipids

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