TY - JOUR
T1 - Rafts defined
T2 - A report on the Keystone symposium on lipid rafts and cell function
AU - Pike, Linda J.
PY - 2006
Y1 - 2006
N2 - The recent Keystone Symposium on Lipid Rafts and Cell Function (March 23-28, 2006 in Steamboat Springs, CO) brought together biophysicists, biochemists, and cell biologists to discuss the structure and function of lipid rafts. What emerged from the meeting was a consensus definition of a membrane raft: "Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and proteinlipid interactions." This definition helps to clarify current thinking in a field that has been plagued by the heterogeneous and sometimes ephemeral nature of its subject.
AB - The recent Keystone Symposium on Lipid Rafts and Cell Function (March 23-28, 2006 in Steamboat Springs, CO) brought together biophysicists, biochemists, and cell biologists to discuss the structure and function of lipid rafts. What emerged from the meeting was a consensus definition of a membrane raft: "Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and proteinlipid interactions." This definition helps to clarify current thinking in a field that has been plagued by the heterogeneous and sometimes ephemeral nature of its subject.
KW - Cholesterol
KW - Membrane microdomains
KW - Sphingolipids
UR - http://www.scopus.com/inward/record.url?scp=33746085241&partnerID=8YFLogxK
U2 - 10.1194/jlr.E600002-JLR200
DO - 10.1194/jlr.E600002-JLR200
M3 - Article
C2 - 16645198
AN - SCOPUS:33746085241
SN - 0022-2275
VL - 47
SP - 1597
EP - 1598
JO - Journal of lipid research
JF - Journal of lipid research
IS - 7
ER -