Radiosynthesis of [11C]paclitaxel

Hayden T. Ravert; Raymond W. Klecker; Jerry M. Collins; William B. Mathews; Martin G. Pomper; Richard L. Wahl; Robert F. Dannals

doi:10.1002/jlcr.571

Radiosynthesis of [¹¹C]paclitaxel

Hayden T. Ravert, Raymond W. Klecker, Jerry M. Collins, William B. Mathews, Martin G. Pomper, Richard L. Wahl, Robert F. Dannals

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

[¹¹C]paclitaxel, a potential solid tumor imaging agent, was synthesized by reacting [α-¹¹C]benzoyl chloride with the primary amine precursor of paclitaxel. The time for synthesis, purification, and formulation was 38 min from end of bombardment with an average specific radioactivity of 49.9 GBq/μmol (1349 mCi/μmol) at end of synthesis. The average decay corrected radiochemical yield was 7% with greater than 99% radiochemical purity.

Original language	English
Pages (from-to)	471-477
Number of pages	7
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	45
Issue number	6
DOIs	https://doi.org/10.1002/jlcr.571
State	Published - 2002

Keywords

Anticancer
Carbon-11
Microtubule
Paclitaxel
Positron emission tomography

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title = "Radiosynthesis of [11C]paclitaxel",

abstract = "[11C]paclitaxel, a potential solid tumor imaging agent, was synthesized by reacting [α-11C]benzoyl chloride with the primary amine precursor of paclitaxel. The time for synthesis, purification, and formulation was 38 min from end of bombardment with an average specific radioactivity of 49.9 GBq/μmol (1349 mCi/μmol) at end of synthesis. The average decay corrected radiochemical yield was 7% with greater than 99% radiochemical purity.",

keywords = "Anticancer, Carbon-11, Microtubule, Paclitaxel, Positron emission tomography",

author = "Ravert, {Hayden T.} and Klecker, {Raymond W.} and Collins, {Jerry M.} and Mathews, {William B.} and Pomper, {Martin G.} and Wahl, {Richard L.} and Dannals, {Robert F.}",

year = "2002",

doi = "10.1002/jlcr.571",

language = "English",

volume = "45",

pages = "471--477",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

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T1 - Radiosynthesis of [11C]paclitaxel

AU - Ravert, Hayden T.

AU - Klecker, Raymond W.

AU - Collins, Jerry M.

AU - Mathews, William B.

AU - Pomper, Martin G.

AU - Wahl, Richard L.

AU - Dannals, Robert F.

PY - 2002

Y1 - 2002

N2 - [11C]paclitaxel, a potential solid tumor imaging agent, was synthesized by reacting [α-11C]benzoyl chloride with the primary amine precursor of paclitaxel. The time for synthesis, purification, and formulation was 38 min from end of bombardment with an average specific radioactivity of 49.9 GBq/μmol (1349 mCi/μmol) at end of synthesis. The average decay corrected radiochemical yield was 7% with greater than 99% radiochemical purity.

AB - [11C]paclitaxel, a potential solid tumor imaging agent, was synthesized by reacting [α-11C]benzoyl chloride with the primary amine precursor of paclitaxel. The time for synthesis, purification, and formulation was 38 min from end of bombardment with an average specific radioactivity of 49.9 GBq/μmol (1349 mCi/μmol) at end of synthesis. The average decay corrected radiochemical yield was 7% with greater than 99% radiochemical purity.

KW - Anticancer

KW - Carbon-11

KW - Microtubule

KW - Paclitaxel

KW - Positron emission tomography

UR - http://www.scopus.com/inward/record.url?scp=0036272621&partnerID=8YFLogxK

U2 - 10.1002/jlcr.571

DO - 10.1002/jlcr.571

M3 - Article

AN - SCOPUS:0036272621

SN - 0362-4803

VL - 45

SP - 471

EP - 477

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 6

ER -

Radiosynthesis of [¹¹C]paclitaxel

Abstract

Keywords

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