Radiosynthesis of (N-[11C]methyl)benperidol for PET investigation of D2 receptor binding

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A procedure for the reliable production of the novel PET D2 receptor ligand (N-[11C]methyl)benperidol ([11C]NMB) is described. The method is based on N-methylation of benperidol using [11C]methyl iodide from the PETtrace MeI MicroLab, with product purification via normal-phase HPLC. Batch yields of 2.5 ± 0.9 GBq (68 ± 25 mCi) of [11C]NMB are routinely (n = 16) obtained, with a radiochemical purity > 98% and an average specific activity of over 40.7 TBq (1100 Ci)/mmol. The overall radiosynthesis, purification, and pre-release quality control testing is accomplished within 50 minutes. The procedure described herein produces a radiopharmaceutical product that is suitable for D2 receptor studies using PET or microPET imaging.

Original languageEnglish
Pages (from-to)333-339
Number of pages7
JournalRadiochimica Acta
Volume92
Issue number4-6
DOIs
StatePublished - 2004

Keywords

  • (N-[C]methyl)benperidol
  • Dopamine
  • Dopamine D2 receptors
  • PET
  • Radiopharmaceutical
  • [C]NMB

Fingerprint Dive into the research topics of 'Radiosynthesis of (N-[<sup>11</sup>C]methyl)benperidol for PET investigation of D2 receptor binding'. Together they form a unique fingerprint.

Cite this