Abstract
A procedure for the reliable production of the novel PET D2 receptor ligand (N-[11C]methyl)benperidol ([11C]NMB) is described. The method is based on N-methylation of benperidol using [11C]methyl iodide from the PETtrace MeI MicroLab, with product purification via normal-phase HPLC. Batch yields of 2.5 ± 0.9 GBq (68 ± 25 mCi) of [11C]NMB are routinely (n = 16) obtained, with a radiochemical purity > 98% and an average specific activity of over 40.7 TBq (1100 Ci)/mmol. The overall radiosynthesis, purification, and pre-release quality control testing is accomplished within 50 minutes. The procedure described herein produces a radiopharmaceutical product that is suitable for D2 receptor studies using PET or microPET imaging.
Original language | English |
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Pages (from-to) | 333-339 |
Number of pages | 7 |
Journal | Radiochimica Acta |
Volume | 92 |
Issue number | 4-6 |
DOIs | |
State | Published - 2004 |
Keywords
- (N-[C]methyl)benperidol
- Dopamine
- Dopamine D2 receptors
- PET
- Radiopharmaceutical
- [C]NMB