TY - JOUR
T1 - Radiosynthesis of high effective specific-activity [123I]SCH 23982 for dopamine D-1 receptor-based SPECT imaging
AU - Moerlein, Stephen M.
AU - Parkinson, David
AU - Welch, Michael J.
N1 - Funding Information:
Acknowledgements-This work was supported by NIH Grant lR29NS26788, Animal Resources Program, University of Washington Regional Primate Center Grant RR 00166, DOE Grant DE-FG02-84ER60218 and a Grant from Mallinckrodt, Inc.
PY - 1990
Y1 - 1990
N2 - The high yield, high-specific activity radiosynthesis of the dopaminergic D-1 receptor-binding ligand [123I]SCH 23982 is described. Using no-carrier-added iododeprotonation of the des-iodo precursor SKF 83692 and column-switching HPLC, [123I]SCH 23982 was isolated in 35-40% radiochemical yield with an effective specific activity of 2250-4000 Ci/mmol and an overall preparation time of 90 min. The procedure outlined here can be employed for the clinical production of [123I]SCH 23982 as a SPECT radiopharmaceutical, as well as [125I]SCH 23982 to be used for in vitro receptor-binding applications.
AB - The high yield, high-specific activity radiosynthesis of the dopaminergic D-1 receptor-binding ligand [123I]SCH 23982 is described. Using no-carrier-added iododeprotonation of the des-iodo precursor SKF 83692 and column-switching HPLC, [123I]SCH 23982 was isolated in 35-40% radiochemical yield with an effective specific activity of 2250-4000 Ci/mmol and an overall preparation time of 90 min. The procedure outlined here can be employed for the clinical production of [123I]SCH 23982 as a SPECT radiopharmaceutical, as well as [125I]SCH 23982 to be used for in vitro receptor-binding applications.
UR - http://www.scopus.com/inward/record.url?scp=0025287065&partnerID=8YFLogxK
U2 - 10.1016/0883-2889(90)90147-9
DO - 10.1016/0883-2889(90)90147-9
M3 - Article
C2 - 2158956
AN - SCOPUS:0025287065
SN - 0883-2889
VL - 41
SP - 381
EP - 385
JO - International Journal of Radiation Applications and Instrumentation. Part
JF - International Journal of Radiation Applications and Instrumentation. Part
IS - 4
ER -