Radiosynthesis of a selective dopamine D-1 receptor antagonist: R(+)-7-chloro-8-hydroxy-3-[11C]methyl-1-phenyl-2,3,4,5-tetrah ydro-1H-3-benzazepine ([11C]SCH 23390)

Hayden T. Ravert; Alan A. Wilson; Robert F. Dannals; Dean F. Wong; Henry N. Wagner

doi:10.1016/0883-2889(87)90045-1

Radiosynthesis of a selective dopamine D-1 receptor antagonist: R(+)-7-chloro-8-hydroxy-3-[¹¹C]methyl-1-phenyl-2,3,4,5-tetrah ydro-¹H-3-benzazepine ([¹¹C]SCH 23390)

Hayden T. Ravert
, Alan A. Wilson
, Robert F. Dannals
, Dean F. Wong
, Henry N. Wagner

Precision Radiotheranostics Translation Center (PRTC)

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Carbon-11 labeled SCH 23390, a selective dopamine D-1 receptor antagonist (Fig. 1b), was prepared by N-alkylation of the nor-methyl precursor with [¹¹C]iodomethane. The product was purified by semi-preparative HPLC and shown to be radiochemically pure at the end of synthesis. The synthesis was completed in approximately 22 min with an average radiochemical yield of 28% (based on [¹¹C]iodomethane) and an average specific activity of approximately 1950 mCi/μmol calculated at the end of synthesis.

Original language	English
Pages (from-to)	305-306
Number of pages	2
Journal	International Journal of Radiation Applications and Instrumentation. Part
Volume	38
Issue number	4
DOIs	https://doi.org/10.1016/0883-2889(87)90045-1
State	Published - 1987

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10.1016/0883-2889(87)90045-1

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Ravert, H. T., Wilson, A. A., Dannals, R. F., Wong, D. F., & Wagner, H. N. (1987). Radiosynthesis of a selective dopamine D-1 receptor antagonist: R(+)-7-chloro-8-hydroxy-3-[¹¹C]methyl-1-phenyl-2,3,4,5-tetrah ydro-¹H-3-benzazepine ([¹¹C]SCH 23390). International Journal of Radiation Applications and Instrumentation. Part, 38(4), 305-306. https://doi.org/10.1016/0883-2889(87)90045-1

@article{874c25e2872f468299eb30fd9e85db57,

title = "Radiosynthesis of a selective dopamine D-1 receptor antagonist: R(+)-7-chloro-8-hydroxy-3-[11C]methyl-1-phenyl-2,3,4,5-tetrah ydro-1H-3-benzazepine ([11C]SCH 23390)",

abstract = "Carbon-11 labeled SCH 23390, a selective dopamine D-1 receptor antagonist (Fig. 1b), was prepared by N-alkylation of the nor-methyl precursor with [11C]iodomethane. The product was purified by semi-preparative HPLC and shown to be radiochemically pure at the end of synthesis. The synthesis was completed in approximately 22 min with an average radiochemical yield of 28\% (based on [11C]iodomethane) and an average specific activity of approximately 1950 mCi/μmol calculated at the end of synthesis.",

author = "Ravert, \{Hayden T.\} and Wilson, \{Alan A.\} and Dannals, \{Robert F.\} and Wong, \{Dean F.\} and Wagner, \{Henry N.\}",

note = "Funding Information: Acknowledgements-Thisw ork was supportedi n part by U.S.P.H.S. Grant No. NS-15080T. he authorsa cknowledge FrederickW . Gilbart for operatingt he cyclotrona nd assisting with the radiochemicasl ynthesesT. he authorsw ould like to thankD r Claus Braestrupo f Novo Pharmaceuticals R \& D, Denmarkf or providings ampleso f the compounds usedi n this work.",

year = "1987",

doi = "10.1016/0883-2889(87)90045-1",

language = "English",

volume = "38",

pages = "305--306",

journal = "International Journal of Radiation Applications and Instrumentation. Part",

issn = "0883-2889",

number = "4",

}

Ravert, HT, Wilson, AA, Dannals, RF, Wong, DF & Wagner, HN 1987, 'Radiosynthesis of a selective dopamine D-1 receptor antagonist: R(+)-7-chloro-8-hydroxy-3-[¹¹C]methyl-1-phenyl-2,3,4,5-tetrah ydro-¹H-3-benzazepine ([¹¹C]SCH 23390)', International Journal of Radiation Applications and Instrumentation. Part, vol. 38, no. 4, pp. 305-306. https://doi.org/10.1016/0883-2889(87)90045-1

Radiosynthesis of a selective dopamine D-1 receptor antagonist: R(+)-7-chloro-8-hydroxy-3-[¹¹C]methyl-1-phenyl-2,3,4,5-tetrah ydro-¹H-3-benzazepine ([¹¹C]SCH 23390). / Ravert, Hayden T.; Wilson, Alan A.; Dannals, Robert F. et al.
In: International Journal of Radiation Applications and Instrumentation. Part, Vol. 38, No. 4, 1987, p. 305-306.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Radiosynthesis of a selective dopamine D-1 receptor antagonist

T2 - R(+)-7-chloro-8-hydroxy-3-[11C]methyl-1-phenyl-2,3,4,5-tetrah ydro-1H-3-benzazepine ([11C]SCH 23390)

AU - Ravert, Hayden T.

AU - Wilson, Alan A.

AU - Dannals, Robert F.

AU - Wong, Dean F.

AU - Wagner, Henry N.

N1 - Funding Information: Acknowledgements-Thisw ork was supportedi n part by U.S.P.H.S. Grant No. NS-15080T. he authorsa cknowledge FrederickW . Gilbart for operatingt he cyclotrona nd assisting with the radiochemicasl ynthesesT. he authorsw ould like to thankD r Claus Braestrupo f Novo Pharmaceuticals R & D, Denmarkf or providings ampleso f the compounds usedi n this work.

PY - 1987

Y1 - 1987

N2 - Carbon-11 labeled SCH 23390, a selective dopamine D-1 receptor antagonist (Fig. 1b), was prepared by N-alkylation of the nor-methyl precursor with [11C]iodomethane. The product was purified by semi-preparative HPLC and shown to be radiochemically pure at the end of synthesis. The synthesis was completed in approximately 22 min with an average radiochemical yield of 28% (based on [11C]iodomethane) and an average specific activity of approximately 1950 mCi/μmol calculated at the end of synthesis.

AB - Carbon-11 labeled SCH 23390, a selective dopamine D-1 receptor antagonist (Fig. 1b), was prepared by N-alkylation of the nor-methyl precursor with [11C]iodomethane. The product was purified by semi-preparative HPLC and shown to be radiochemically pure at the end of synthesis. The synthesis was completed in approximately 22 min with an average radiochemical yield of 28% (based on [11C]iodomethane) and an average specific activity of approximately 1950 mCi/μmol calculated at the end of synthesis.

UR - https://www.scopus.com/pages/publications/0023223169

U2 - 10.1016/0883-2889(87)90045-1

DO - 10.1016/0883-2889(87)90045-1

M3 - Article

C2 - 3040632

AN - SCOPUS:0023223169

SN - 0883-2889

VL - 38

SP - 305

EP - 306

JO - International Journal of Radiation Applications and Instrumentation. Part

JF - International Journal of Radiation Applications and Instrumentation. Part

IS - 4

ER -

Radiosynthesis of a selective dopamine D-1 receptor antagonist: R(+)-7-chloro-8-hydroxy-3-[¹¹C]methyl-1-phenyl-2,3,4,5-tetrah ydro-¹H-3-benzazepine ([¹¹C]SCH 23390)

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