@article{874c25e2872f468299eb30fd9e85db57,
title = "Radiosynthesis of a selective dopamine D-1 receptor antagonist: R(+)-7-chloro-8-hydroxy-3-[11C]methyl-1-phenyl-2,3,4,5-tetrah ydro-1H-3-benzazepine ([11C]SCH 23390)",
abstract = "Carbon-11 labeled SCH 23390, a selective dopamine D-1 receptor antagonist (Fig. 1b), was prepared by N-alkylation of the nor-methyl precursor with [11C]iodomethane. The product was purified by semi-preparative HPLC and shown to be radiochemically pure at the end of synthesis. The synthesis was completed in approximately 22 min with an average radiochemical yield of 28\% (based on [11C]iodomethane) and an average specific activity of approximately 1950 mCi/μmol calculated at the end of synthesis.",
author = "Ravert, \{Hayden T.\} and Wilson, \{Alan A.\} and Dannals, \{Robert F.\} and Wong, \{Dean F.\} and Wagner, \{Henry N.\}",
note = "Funding Information: Acknowledgements-Thisw ork was supportedi n part by U.S.P.H.S. Grant No. NS-15080T. he authorsa cknowledge FrederickW . Gilbart for operatingt he cyclotrona nd assisting with the radiochemicasl ynthesesT. he authorsw ould like to thankD r Claus Braestrupo f Novo Pharmaceuticals R \& D, Denmarkf or providings ampleso f the compounds usedi n this work.",
year = "1987",
doi = "10.1016/0883-2889(87)90045-1",
language = "English",
volume = "38",
pages = "305--306",
journal = "International Journal of Radiation Applications and Instrumentation. Part",
issn = "0883-2889",
number = "4",
}