Radiosynthesis of a selective dopamine D-1 receptor antagonist: R(+)-7-chloro-8-hydroxy-3-[11C]methyl-1-phenyl-2,3,4,5-tetrah ydro-1H-3-benzazepine ([11C]SCH 23390)

Hayden T. Ravert, Alan A. Wilson, Robert F. Dannals, Dean F. Wong, Henry N. Wagner

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21 Scopus citations

Abstract

Carbon-11 labeled SCH 23390, a selective dopamine D-1 receptor antagonist (Fig. 1b), was prepared by N-alkylation of the nor-methyl precursor with [11C]iodomethane. The product was purified by semi-preparative HPLC and shown to be radiochemically pure at the end of synthesis. The synthesis was completed in approximately 22 min with an average radiochemical yield of 28% (based on [11C]iodomethane) and an average specific activity of approximately 1950 mCi/μmol calculated at the end of synthesis.

Original languageEnglish
Pages (from-to)305-306
Number of pages2
JournalInternational Journal of Radiation Applications and Instrumentation. Part
Volume38
Issue number4
DOIs
StatePublished - 1987

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