Radiosynthesis of a ligand for studying the glycine transporter: [11C]ALX-5407

Hayden T. Ravert; William B. Mathews; Mark A. Klitenick; Dean F. Wong; Robert F. Dannals

doi:10.1002/jlcr.453

Radiosynthesis of a ligand for studying the glycine transporter: [¹¹C]ALX-5407

Hayden T. Ravert
, William B. Mathews
, Mark A. Klitenick
, Dean F. Wong
, Robert F. Dannals

Precision Radiotheranostics Translation Center (PRTC)

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

[¹¹C]ALX-5407, R-N[3-(4′-fluorophenyl)-3-(4′-phenylphenoxy)propyl] sarcosine, a chiral glycine transporter 1 antagonist, was labeled with [¹¹C]iodomethane by N-alkylation of methyl ester protected N-normethyl precursor, ALX-5536, and subsequent saponification of the methyl ester protecting group. The time for synthesis, purification, and formulation was 33 minutes with an average specific radioactivity of 3909 mCi/μmol (EOS) and average decay corrected radiochemical yield of 8%.

Original language	English
Pages (from-to)	241-246
Number of pages	6
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	44
Issue number	3
DOIs	https://doi.org/10.1002/jlcr.453
State	Published - 2001

Keywords

ALX-5407
Carbon-11
GlyT1
Glycine
Glycine transporter
Positron emission tomography

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10.1002/jlcr.453

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@article{a5040ada0bc049dc963ad751f336e888,

title = "Radiosynthesis of a ligand for studying the glycine transporter: [11C]ALX-5407",

abstract = "[11C]ALX-5407, R-N[3-(4′-fluorophenyl)-3-(4′-phenylphenoxy)propyl] sarcosine, a chiral glycine transporter 1 antagonist, was labeled with [11C]iodomethane by N-alkylation of methyl ester protected N-normethyl precursor, ALX-5536, and subsequent saponification of the methyl ester protecting group. The time for synthesis, purification, and formulation was 33 minutes with an average specific radioactivity of 3909 mCi/μmol (EOS) and average decay corrected radiochemical yield of 8\%.",

keywords = "ALX-5407, Carbon-11, GlyT1, Glycine, Glycine transporter, Positron emission tomography",

author = "Ravert, \{Hayden T.\} and Mathews, \{William B.\} and Klitenick, \{Mark A.\} and Wong, \{Dean F.\} and Dannals, \{Robert F.\}",

year = "2001",

doi = "10.1002/jlcr.453",

language = "English",

volume = "44",

pages = "241--246",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

issn = "0362-4803",

number = "3",

}

TY - JOUR

T1 - Radiosynthesis of a ligand for studying the glycine transporter

T2 - [11C]ALX-5407

AU - Ravert, Hayden T.

AU - Mathews, William B.

AU - Klitenick, Mark A.

AU - Wong, Dean F.

AU - Dannals, Robert F.

PY - 2001

Y1 - 2001

N2 - [11C]ALX-5407, R-N[3-(4′-fluorophenyl)-3-(4′-phenylphenoxy)propyl] sarcosine, a chiral glycine transporter 1 antagonist, was labeled with [11C]iodomethane by N-alkylation of methyl ester protected N-normethyl precursor, ALX-5536, and subsequent saponification of the methyl ester protecting group. The time for synthesis, purification, and formulation was 33 minutes with an average specific radioactivity of 3909 mCi/μmol (EOS) and average decay corrected radiochemical yield of 8%.

AB - [11C]ALX-5407, R-N[3-(4′-fluorophenyl)-3-(4′-phenylphenoxy)propyl] sarcosine, a chiral glycine transporter 1 antagonist, was labeled with [11C]iodomethane by N-alkylation of methyl ester protected N-normethyl precursor, ALX-5536, and subsequent saponification of the methyl ester protecting group. The time for synthesis, purification, and formulation was 33 minutes with an average specific radioactivity of 3909 mCi/μmol (EOS) and average decay corrected radiochemical yield of 8%.

KW - ALX-5407

KW - Carbon-11

KW - GlyT1

KW - Glycine

KW - Glycine transporter

KW - Positron emission tomography

UR - https://www.scopus.com/pages/publications/0035106194

U2 - 10.1002/jlcr.453

DO - 10.1002/jlcr.453

M3 - Article

AN - SCOPUS:0035106194

SN - 0362-4803

VL - 44

SP - 241

EP - 246

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 3

ER -

Radiosynthesis of a ligand for studying the glycine transporter: [¹¹C]ALX-5407

Abstract

Keywords

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