Abstract
[11C]ALX-5407, R-N[3-(4′-fluorophenyl)-3-(4′-phenylphenoxy)propyl] sarcosine, a chiral glycine transporter 1 antagonist, was labeled with [11C]iodomethane by N-alkylation of methyl ester protected N-normethyl precursor, ALX-5536, and subsequent saponification of the methyl ester protecting group. The time for synthesis, purification, and formulation was 33 minutes with an average specific radioactivity of 3909 mCi/μmol (EOS) and average decay corrected radiochemical yield of 8%.
Original language | English |
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Pages (from-to) | 241-246 |
Number of pages | 6 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 44 |
Issue number | 3 |
DOIs | |
State | Published - 2001 |
Keywords
- ALX-5407
- Carbon-11
- GlyT1
- Glycine
- Glycine transporter
- Positron emission tomography