Radiosynthesis and biological evaluation of alpha-[F-18]fluoromethyl phenylalanine for brain tumor imaging

Keyphrases

• 18F-fluoride 33%
• 18F-fluorination 33%
• Amino Acid Transport 33%
• Balb C Mice 33%
• Biodistribution 100%
• Biodistribution Studies 33%
• Biological Evaluation 100%
• Brain Availability 33%
• Brain Tumor 33%
• Cell Uptake 66%
• Chiral HPLC 33%
• Commercially Available 33%
• CT Studies 33%
• Cyclic Sulfamidate 100%
• D-amino Acids 33%
• Deprotection 33%
• F-18 100%
• Fluorine Groups 33%
• Fluoromethylation 100%
• Good Yield 33%
• High-grade Glioma 33%
• Image Properties 33%
• In Vitro Uptake 66%
• Inhibition Assay 33%
• Low Uptake 33%
• MicroPET 100%
• MicroPET Imaging 33%
• MRI Brain Tumor 100%
• New Tracer 33%
• Non-radioactive 33%
• Nucleophilic 33%
• Nucleophilic Reaction 33%
• PET Tracer 33%
• Phenylalanine 100%
• Phenylalanine Derivatives 33%
• Racemic 100%
• Radioactivity 33%
• Radiochemical Purity 33%
• Radiochemical Yield 66%
• Radiolabeled Amino Acids 33%
• Radiosynthesis 100%
• Rapid Uptake 33%
• Reaction Conditions 33%
• Single Enantiomer 33%
• Tumor 33%
• Tumor Cells 66%
• Tumor Imaging 33%
• Tumor Uptake 100%
• Tumor Visualization 66%
• Tumor-to-brain Ratio 33%
• Uptake Assay 33%
• Uptake Inhibition 33%

Medicine and Dentistry

• Amino Acid 6%
• Amino Acid Transporter 6%
• Biodistribution 25%
• Fluorine-18 100%
• Ganglioglioma 6%
• High-Performance Liquid Chromatography 6%
• In Vitro 12%
• Intracranial Tumor 100%
• Neoplasm 43%
• Phenylalanine 100%
• Polyethylene Terephthalate 6%
• Precursor 25%
• Radioactive Tracer 18%
• Tumor Cell 12%
• Tumor Imaging 100%
• Uptake Assay 6%

Pharmacology, Toxicology and Pharmaceutical Science

• Amino Acid 6%
• Amino Acid Transporter 6%
• Bagg Albino Mouse 6%
• Biodistribution 25%
• Fluorine 18 100%
• Glioma 6%
• High Performance Liquid Chromatography 6%
• Intracranial Tumor 100%
• Neoplasm 62%
• Phenylalanine 100%
• Polyethylene Terephthalate 6%
• Tracer 18%