Radioprotection by DMSO against the biological effects of incorporated radionuclides in vivo. Comparison with other radioprotectors and evidence for indirect action of Auger electrons

S. Murty Goddu, Venkat R. Narra, Ravi S. Harapanhalli, Roger W. Howell, Dandamudi V. Rao

Research output: Contribution to journalConference articlepeer-review

19 Scopus citations

Abstract

Dimethyl sulfoxide (DMSO) was studied for its capacity to protect against the biological effects of chronic irradiation by incorporated radionuclides. Spermatogenesis in mice was used as experimental model and spermatogonial cell survival was the biological endpoint. DMSO was injected intratesticularly 4 h prior to a similar injection of the radiochemical and the spermhead survival determined. Iodine-125 was localized in either the cytoplasm (H125IPDM) or in the DNA (125IUdR) of the testicular cells. Protection was observed against the high-LET type effects of DNA-bound 125I as well as the low-LET effects of cytoplasmically localized 125I with dose modification factors (DMF) of 3.1 ± 1.0 and 4.4 ± 1.0 respectively. No protection (DMF = 1.1 ± 0.1) was observed against the effects of high-LET 5.3 MeV alpha particles of 210Po. The present findings provide supporting evidence that the mechanism responsible for the extreme biological damage caused by DNA-bound Auger emitters is largely radical mediated and therefore indirect in nature.

Original languageEnglish
Pages (from-to)901-907
Number of pages7
JournalActa Oncologica
Volume35
Issue number7
DOIs
StatePublished - Jan 1 1996
Externally publishedYes
EventProceedings of the 1995 3rd International Symposium on Biophysical Aspects of Auger Processes - Lund, Swed
Duration: Aug 24 1995Aug 25 1995

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