Radionuclide imaging metabolic activity of brown adipose tissue in a patient with pheochromocytoma

Kazuki Fukuchi, M. Tatsumi, Y. Ishida, N. Oku, J. Hatazawa, R. L. Wahl

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

We describe a patient with extra-adrenal pheochmmocytoma and high plasma norepinephrine levels. Radionuclide images of this patient obtained using 18F-fluorodeoxyglucose and 123I-metaiodobenzylguanidine revealed bilateral tracer accumulation in the shoulder and lower neck. The regions of radiotracer uptake corresponded to the location of human brown adipose tissue (BAT). Excessive sympathetic stimulation by high circulating catecholamine concentrations augmented the metabolic activity and tracer uptake in the BAT. This study showed that radionuclide imaging can noninvasively visualize human BAT in terms of metabolic and functional activity.

Original languageEnglish
Pages (from-to)601-603
Number of pages3
JournalExperimental and Clinical Endocrinology and Diabetes
Volume112
Issue number10
DOIs
StatePublished - Nov 1 2004
Externally publishedYes

Keywords

  • Fat
  • Pheochromocytoma
  • Positron emission tomography (PET)
  • Radionuclide imaging

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