Radionuclide evaluation of pulmonary function following hemithorax irradiation of normal dogs with 60Co or fast neutrons

P. O. Alderson; E. W. Bradley; K. G. Mendenhall; F. Vieras; B. A. Siegel; G. E. Sloan; C. C. Rogers

doi:10.1148/130.2.425

Radionuclide evaluation of pulmonary function following hemithorax irradiation of normal dogs with ⁶⁰Co or fast neutrons

P. O. Alderson, E. W. Bradley, K. G. Mendenhall, F. Vieras, B. A. Siegel, G. E. Sloan, C. C. Rogers

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Abstract

To assess the effects of therapeutic doses of radiation on regional pulmonary function, 28 dogs had serial chest radiographs and quantitative ventilation, perfusion and aerosol studies at three-, six-, nine- and twelve-month intervals after hemithorax irradiation with ⁶⁰Co-gamma photons or 15-MeV fast neutrons. Findings showed marked reductions in perfusion and aerosol deposition in the irradiated lungs of dogs in the high-dose photon and neutron groups and in the medium-dose neutron group. The effects of large photon and small neutron doses were similar (neutron RBE = 4.5). Radionuclide studies were found to be useful for detecting these alterations.

Original language	English
Pages (from-to)	425-433
Number of pages	9
Journal	Unknown Journal
Volume	130
Issue number	2
DOIs	https://doi.org/10.1148/130.2.425
State	Published - 1979

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10.1148/130.2.425

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title = "Radionuclide evaluation of pulmonary function following hemithorax irradiation of normal dogs with 60Co or fast neutrons",

abstract = "To assess the effects of therapeutic doses of radiation on regional pulmonary function, 28 dogs had serial chest radiographs and quantitative ventilation, perfusion and aerosol studies at three-, six-, nine- and twelve-month intervals after hemithorax irradiation with 60Co-gamma photons or 15-MeV fast neutrons. Findings showed marked reductions in perfusion and aerosol deposition in the irradiated lungs of dogs in the high-dose photon and neutron groups and in the medium-dose neutron group. The effects of large photon and small neutron doses were similar (neutron RBE = 4.5). Radionuclide studies were found to be useful for detecting these alterations.",

author = "Alderson, {P. O.} and Bradley, {E. W.} and Mendenhall, {K. G.} and F. Vieras and Siegel, {B. A.} and Sloan, {G. E.} and Rogers, {C. C.}",

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AU - Alderson, P. O.

AU - Bradley, E. W.

AU - Mendenhall, K. G.

AU - Vieras, F.

AU - Siegel, B. A.

AU - Sloan, G. E.

AU - Rogers, C. C.

PY - 1979

Y1 - 1979

N2 - To assess the effects of therapeutic doses of radiation on regional pulmonary function, 28 dogs had serial chest radiographs and quantitative ventilation, perfusion and aerosol studies at three-, six-, nine- and twelve-month intervals after hemithorax irradiation with 60Co-gamma photons or 15-MeV fast neutrons. Findings showed marked reductions in perfusion and aerosol deposition in the irradiated lungs of dogs in the high-dose photon and neutron groups and in the medium-dose neutron group. The effects of large photon and small neutron doses were similar (neutron RBE = 4.5). Radionuclide studies were found to be useful for detecting these alterations.

AB - To assess the effects of therapeutic doses of radiation on regional pulmonary function, 28 dogs had serial chest radiographs and quantitative ventilation, perfusion and aerosol studies at three-, six-, nine- and twelve-month intervals after hemithorax irradiation with 60Co-gamma photons or 15-MeV fast neutrons. Findings showed marked reductions in perfusion and aerosol deposition in the irradiated lungs of dogs in the high-dose photon and neutron groups and in the medium-dose neutron group. The effects of large photon and small neutron doses were similar (neutron RBE = 4.5). Radionuclide studies were found to be useful for detecting these alterations.

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SP - 425

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JO - Unknown Journal

JF - Unknown Journal

IS - 2

ER -

Radionuclide evaluation of pulmonary function following hemithorax irradiation of normal dogs with ⁶⁰Co or fast neutrons

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