Radionuclide angiocardiography. Improved diagnosis and quantitation of left to right shunts using area ratio techniques in children

P. O. Alderson, R. G. Jost, A. W. Strauss, S. Boonvisut, J. Markham

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

A comparison of several reported methods for detection and quantitation of left to right shunts by radionuclides was performed in 50 children. Count ratio (C2/C1) techniques were compared with the exponential extrapolation and gamma function area ratio techniques. C2/C1 ratios accurately detected shunts and could reliably separate shunts from normals, but there was a high rate of false positives in children with valvular heart disease. The area ratio methods provided more accurate shunt quantitation and a better separation of patients with valvular heart disease than did the C2/C1 ratio. The gamma function method showed a higher correlation with oximetry than the exponential method, but the difference was not statistically significant. For accurate shunt quantitation and a reliable separation of patients with valvular heart disease from those with shunts, area ratio calculations are preferable to the C2/C1 ratio.

Original languageEnglish
Pages (from-to)1136-1143
Number of pages8
JournalUnknown Journal
Volume51
Issue number6
DOIs
StatePublished - 1975

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