Degenerative spondyloarthropathy is the result of a number of related pathologic processes, including loss of disc elasticity, repetitive mild trauma, and osteoporosis. The effects are manifested microscopically in a number of patterns reflecting alterations in stress, healing microfractures, and bone-cartilage interactions along the vertebral end-plate. The microscopic changes lead in turn to radiographically evident vertebral body sclerosis. The resultant sclerosis is not always in the classic band-like pattern along the vertebral end-plate, and the atypical patterns may be difficult to recognize as degenerative in origin. In a detailed analysis of clinical and postmortem material, we have categorized both the pathologic and radiographic patterns of benign non-Pagetic vertebral body sclerosis. This radiographic classification provides a unified framework for clinical recognition of the various patterns of degenerative sclerosis.

Original languageEnglish
Pages (from-to)447-454
Number of pages8
JournalInvestigative Radiology
Issue number6
StatePublished - Jun 1988


  • Degenerative disc disease
  • Sclerosis
  • Spine
  • Spondylo-sclerosis
  • Vertebral bodies


Dive into the research topics of 'Radiologic and pathologic patterns of end-plate–based vertebral sclerosis'. Together they form a unique fingerprint.

Cite this