Radiolabeled 6-(2, 3-dichlorophenyl)-n4-methylpyrimidine-2, 4-diamine (th287): A potential radiotracer for measuring and imaging mth1

Pharmacology, Toxicology and Pharmaceutical Science

• Carbon 11 100%
• Tracer 100%
• Polyethylene Terephthalate 100%
• Biological Marker 50%
• Glioblastoma 50%
• Cancer Growth 50%
• IC50 50%
• Radioligand 50%
• Tritium 50%
• Crizotinib 50%
• Central Nervous System Disease 50%
• Hydrolase 50%
• Intracranial Tumor 50%
• Nudix Hydrolase 50%
• Nucleoside Triphosphatase 50%
• Purine Nucleoside 50%

Keyphrases

• Radiotracer 100%
• Diamine 100%
• TH287 100%
• MTH1 100%
• MutT Homolog 1 90%
• U251MG 30%
• Competitive Binding Assay 20%
• In Vitro Enzymatic Assay 20%
• Saturation Binding Assays 20%
• Kidney 10%
• Cancer Progression 10%
• High Affinity 10%
• Hydrolase Activity 10%
• Target Engagement 10%
• Radioligand Binding Assay 10%
• Dissociation Constant 10%
• Brain Tumor 10%
• Nervous System Diseases 10%
• Dynamic PET 10%
• MicroPET Imaging 10%
• MicroPET 10%
• IC50 10%
• Tritium 10%
• Crizotinib 10%
• Glioblastoma Cells 10%
• Kinetic Assay 10%
• Rapid Clearance 10%
• Bmax 10%
• Carbon-11 10%
• Purine nucleosides 10%
• NUDT1 10%
• Nudix Hydrolase 10%

Neuroscience

• In Vitro 100%
• In Vivo 66%
• Binding Competition 66%
• Positron Emission Tomography 33%
• Central Nervous System 33%
• Positron Emission Tomography 33%
• Hydrolase 33%
• Radioligand 33%
• Nervous System Disorder 33%
• Nucleoside Triphosphatase 33%
• Purine Nucleoside 33%
• Crizotinib 33%
• Nudix Hydrolase 33%
• Intracranial Tumor 33%