Abstract

Radioimmunotherapy is increasingly used alone and in combination with standard chemotherapy as a preparative conditioning tool for patients with variety of hematological malignancies before allogeneic and autologous stem cell transplantation. This approach, if optimized, has the potential to close the gap between the benefit and toxicity of conditioning regimens. This article is intended to provide a summary of the basic elements of this approach as well as a concise and up-to-date scoping review of the studies that evaluated the safety and efficacy of integrating radioimmunotherapy in the conditioning regimens.

Original languageEnglish
Pages (from-to)389-399
Number of pages11
JournalBlood Reviews
Volume30
Issue number5
DOIs
StatePublished - Sep 1 2016

Keywords

  • Acute myeloid leukemia
  • Alpha emitters
  • Beta emitters
  • Hematopoietic stem cell transplantation
  • Lymphoma
  • Multiple myeloma
  • Pre-targeting
  • Radioimmunotherapy

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