Radiofrequency ablation vs. Cryoablation for localized hepatocellular carcinoma: A propensity-matched population study

Jimmy Xu, Christopher Noda, Abigail Erickson, Mahati Mokkarala, Resmi Charalel, Raja Ramaswamy, Yu Tao, Olaguoke Akinwande

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background/Aim: To compare overall survival (OS) and liver cancer-specific survival (LCSS) of Surveillance, Epidemiology and End Results (SEER) hepatocellular carcinoma (HCC) database patients treated with cryoablation (cryo) or radiofrequency ablation (RFA). Materials and Methods: This was a retrospective review of Stage I or II HCC patients from the SEER database treated with cryo and RFA from 2004-2013. Kaplan-Meier and Cox regressions were performed on pooled and propensity-matched cohort. Results: Out of 3,239 patients, RFA showed a significant survival advantage over cryo in liver cancer specific survival (LCSS) (HR=1.634 p=0.0004). A total of 91 propensity-matched pairs had similar OS (HR=1.006 p=0.9768), but no difference in LCSS was observed between the groups [HR=1.412 (95%CI=0.933-2.137) p=0.1023]. Survival Cox models did not reveal treatment type as an independent prognostic factor. Conclusion: Propensity-matched cohort showed no significant difference in terms of OS and LCSS was found for patients treated with either cryo or RFA for localized HCC.

Original languageEnglish
Pages (from-to)6381-6386
Number of pages6
JournalAnticancer research
Volume38
Issue number11
DOIs
StatePublished - Nov 2018

Keywords

  • Cryoablation
  • Hepatocellular carcinoma
  • Liver cancer specific survival
  • Propensity matching
  • Radiofrequency ablation
  • Surveillance epide-miology and end results database

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