Radioactivity-synchronized fluorescence enhancement using a radionuclide fluorescence-quenched dye

Mikhail Y. Berezin; Kevin Guo; Bao Teng; W. Barry Edwards; Carolyn J. Anderson; Olga Vasalatiy; Amir Gandjbakhche; Gary L. Griffiths; Samuel Achilefu

doi:10.1021/ja903685b

Radioactivity-synchronized fluorescence enhancement using a radionuclide fluorescence-quenched dye

Mikhail Y. Berezin, Kevin Guo, Bao Teng, W. Barry Edwards, Carolyn J. Anderson, Olga Vasalatiy, Amir Gandjbakhche, Gary L. Griffiths, Samuel Achilefu

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

(Chemical Equation Presented) We demonstrate the first evidence of radioactivity-synchronized fluorescence quenching of a near-infrared light-emitting dye by a radionuclide, ⁶⁴Cu, and subsequent fluorescence enhancement upon ⁶⁴Cu decay to the daughter isotopes ⁶⁴Ni and ⁶⁴Zn. The dynamic switch from high radioactivity and low fluorescence to low radioactivity and high fluorescence is potentially useful for developing complementary multimodal imaging and detection platforms for chemical, environmental, and biomedical applications as well as for unraveling the mechanisms of metal-induced dynamic fluorescence changes.

Original language	English
Pages (from-to)	9198-9200
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	131
Issue number	26
DOIs	https://doi.org/10.1021/ja903685b
State	Published - Jul 8 2009

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title = "Radioactivity-synchronized fluorescence enhancement using a radionuclide fluorescence-quenched dye",

abstract = "(Chemical Equation Presented) We demonstrate the first evidence of radioactivity-synchronized fluorescence quenching of a near-infrared light-emitting dye by a radionuclide, 64Cu, and subsequent fluorescence enhancement upon 64Cu decay to the daughter isotopes 64Ni and 64Zn. The dynamic switch from high radioactivity and low fluorescence to low radioactivity and high fluorescence is potentially useful for developing complementary multimodal imaging and detection platforms for chemical, environmental, and biomedical applications as well as for unraveling the mechanisms of metal-induced dynamic fluorescence changes.",

author = "Berezin, {Mikhail Y.} and Kevin Guo and Bao Teng and Edwards, {W. Barry} and Anderson, {Carolyn J.} and Olga Vasalatiy and Amir Gandjbakhche and Griffiths, {Gary L.} and Samuel Achilefu",

year = "2009",

month = jul,

day = "8",

doi = "10.1021/ja903685b",

language = "English",

volume = "131",

pages = "9198--9200",

journal = "Journal of the American Chemical Society",

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number = "26",

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T1 - Radioactivity-synchronized fluorescence enhancement using a radionuclide fluorescence-quenched dye

AU - Berezin, Mikhail Y.

AU - Guo, Kevin

AU - Teng, Bao

AU - Edwards, W. Barry

AU - Anderson, Carolyn J.

AU - Vasalatiy, Olga

AU - Gandjbakhche, Amir

AU - Griffiths, Gary L.

AU - Achilefu, Samuel

PY - 2009/7/8

Y1 - 2009/7/8

N2 - (Chemical Equation Presented) We demonstrate the first evidence of radioactivity-synchronized fluorescence quenching of a near-infrared light-emitting dye by a radionuclide, 64Cu, and subsequent fluorescence enhancement upon 64Cu decay to the daughter isotopes 64Ni and 64Zn. The dynamic switch from high radioactivity and low fluorescence to low radioactivity and high fluorescence is potentially useful for developing complementary multimodal imaging and detection platforms for chemical, environmental, and biomedical applications as well as for unraveling the mechanisms of metal-induced dynamic fluorescence changes.

AB - (Chemical Equation Presented) We demonstrate the first evidence of radioactivity-synchronized fluorescence quenching of a near-infrared light-emitting dye by a radionuclide, 64Cu, and subsequent fluorescence enhancement upon 64Cu decay to the daughter isotopes 64Ni and 64Zn. The dynamic switch from high radioactivity and low fluorescence to low radioactivity and high fluorescence is potentially useful for developing complementary multimodal imaging and detection platforms for chemical, environmental, and biomedical applications as well as for unraveling the mechanisms of metal-induced dynamic fluorescence changes.

UR - http://www.scopus.com/inward/record.url?scp=67649921096&partnerID=8YFLogxK

U2 - 10.1021/ja903685b

DO - 10.1021/ja903685b

M3 - Article

C2 - 19514722

AN - SCOPUS:67649921096

SN - 0002-7863

VL - 131

SP - 9198

EP - 9200

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 26

ER -

Radioactivity-synchronized fluorescence enhancement using a radionuclide fluorescence-quenched dye

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