Radio-Labeled Nanoparticles for Biomedical Imaging

Tolulope Aweda, Deborah Sultan, Yongjian Liu

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

In the field of biomedical imaging, developing delivery systems specific to the target site is an ongoing objective for both therapeutic and imaging applications. Typically, nanoparticles range in size from 1 to 100nm, exhibiting unique size-dependent physical and chemical properties including optical, magnetic, catalytic, thermodynamic, and electrochemical traits. The capacity of radiolabeled nanoparticles to improve the detection limits and resolution of imaging applications is constantly being improved upon. Single-photon emission computed tomography (SPECT) is a powerful nuclear imaging technique that utilizes gamma-emitting radioisotopes to visualize both physiological and functional information at a molecular level. Among molecular imaging modalities, positron emission tomography (PET), due to its high sensitivity, quantitative measurement, limitless depth of tissue penetration, and versatility of chemical probes, has emerged as a major player in nuclear imaging. Radiolabeled nanoparticles have been widely used in biomedical research for drug delivery and diagnostic imaging.

Original languageEnglish
Title of host publicationNanotechnology for Biomedical Imaging and Diagnostics
Subtitle of host publicationFrom Nanoparticle Design to Clinical Applications
Publisherwiley
Pages193-221
Number of pages29
ISBN (Electronic)9781118873151
ISBN (Print)9781118121184
DOIs
StatePublished - Jan 30 2015

Keywords

  • Biomedical imaging
  • Diagnostic imaging
  • Imaging applications
  • Nuclear imaging
  • Positron emission tomography (PET)
  • Radioisotopes
  • Radiolabeled nanoparticles
  • Single-photon emission computed tomography (SPECT)

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