Radical control for enantioselective Csp3–Csp3 cross-coupling

Ju Byeong Chae; Annika R. Holm; Liviu M. Mirica

doi:10.1038/s41929-024-01208-2

Radical control for enantioselective Csp³–Csp³ cross-coupling

Ju Byeong Chae, Annika R. Holm, Liviu M. Mirica

Research output: Contribution to journal › Comment/debate

1 Scopus citations

Abstract

The enantioselective formation of Csp³–Csp³ bonds is still a substantial challenge in the synthesis of complex molecules. Now, a photocatalytic system has been developed for the enantioselective alkylation of α-amino Csp³−H bonds that promotes the generation of two different alkyl radicals, followed by their cross-coupling at a chiral nickel centre.

Original language	English
Pages (from-to)	857-859
Number of pages	3
Journal	Nature Catalysis
Volume	7
Issue number	8
DOIs	https://doi.org/10.1038/s41929-024-01208-2
State	Published - Aug 2024

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title = "Radical control for enantioselective Csp3–Csp3 cross-coupling",

abstract = "The enantioselective formation of Csp3–Csp3 bonds is still a substantial challenge in the synthesis of complex molecules. Now, a photocatalytic system has been developed for the enantioselective alkylation of α-amino Csp3−H bonds that promotes the generation of two different alkyl radicals, followed by their cross-coupling at a chiral nickel centre.",

author = "Chae, {Ju Byeong} and Holm, {Annika R.} and Mirica, {Liviu M.}",

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AU - Chae, Ju Byeong

AU - Holm, Annika R.

AU - Mirica, Liviu M.

N1 - Publisher Copyright: © Springer Nature Limited 2024.

PY - 2024/8

Y1 - 2024/8

N2 - The enantioselective formation of Csp3–Csp3 bonds is still a substantial challenge in the synthesis of complex molecules. Now, a photocatalytic system has been developed for the enantioselective alkylation of α-amino Csp3−H bonds that promotes the generation of two different alkyl radicals, followed by their cross-coupling at a chiral nickel centre.

AB - The enantioselective formation of Csp3–Csp3 bonds is still a substantial challenge in the synthesis of complex molecules. Now, a photocatalytic system has been developed for the enantioselective alkylation of α-amino Csp3−H bonds that promotes the generation of two different alkyl radicals, followed by their cross-coupling at a chiral nickel centre.

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U2 - 10.1038/s41929-024-01208-2

DO - 10.1038/s41929-024-01208-2

M3 - Comment/debate

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SN - 2520-1158

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SP - 857

EP - 859

JO - Nature Catalysis

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Radical control for enantioselective Csp³–Csp³ cross-coupling

Abstract

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