Radiation Therapy Toxicity to the Skin

T. J. FitzGerald, Maryann Bishop Jodoin, Gayle Tillman, Jesse Aronowitz, Richard Pieters, Susan Balducci, Joshua Meyer, M. Giulia Cicchetti, Sidney Kadish, Shelagh McCauley, Joanna Sawicka, Marcia Urie, Y. C. Lo, Charles Mayo, Kenneth Ulin, Linda Ding, Maureen Britton, Jiayi Huang, Edward Arous

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

Radiation therapy has been integral to cancer patient care. The skin is an intentional and unintentional target of therapy, and is sensitive to the volume of normal tissue in the radiation therapy treatment field, daily treatment dose (fractionation), and total treatment dose. We must understand the relationship of these factors to patient outcome as we move toward hypofractionation treatment strategies (radiosurgery). Chemotherapy agents and prescription medications may influence therapy-associated sequelae. Understanding this may prevent significant injury and discomfort. This article reviews established platforms of radiation therapy and sequelae associated with skin therapy. Interactions with other agents and possible predisposition to sequelae are reviewed. Skin cancer resulting from treatment and disease processes associated with possible limited outcome are also reviewed.

Original languageEnglish
Pages (from-to)161-172
Number of pages12
JournalDermatologic Clinics
Volume26
Issue number1
DOIs
StatePublished - Jan 2008

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