Radiation induction of immediate early genes: Effectors of the radiation-stress response

Ralph R. Weichselbaum, Dennis Hallahan, Zvi Fuks, Donald Kufe

Research output: Contribution to journalArticlepeer-review

176 Scopus citations

Abstract

Recent studies have demonstrated that the early response genes c-jun, Egr-1, c-fos, and NFKB are induced following exposure of mammalian cells to ionizing radiation. We propose that the products of these early response genes regulate downstream genes that are important in the adaptation of cells and tissues to radiation-induced stress. Potential downstream targets include cytokine and growth factor genes as well as deoxyribonucleic acid (DNA) repair genes. Early response gene products may also regulate cell cycle progression following cellular x-irradiation. Signal transduction pathways that allow cells to adapt to radiation may provide molecular targets to modify tumor and normal responses to radiotherapy.

Original languageEnglish
Pages (from-to)229-234
Number of pages6
JournalInternational journal of radiation oncology, biology, physics
Volume30
Issue number1
DOIs
StatePublished - Aug 30 1994

Keywords

  • Early response genes
  • Growth factors
  • Radiation mediated transcription
  • Stress response

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