Recent studies have demonstrated that the early response genes c-jun, Egr-1, c-fos, and NFKB are induced following exposure of mammalian cells to ionizing radiation. We propose that the products of these early response genes regulate downstream genes that are important in the adaptation of cells and tissues to radiation-induced stress. Potential downstream targets include cytokine and growth factor genes as well as deoxyribonucleic acid (DNA) repair genes. Early response gene products may also regulate cell cycle progression following cellular x-irradiation. Signal transduction pathways that allow cells to adapt to radiation may provide molecular targets to modify tumor and normal responses to radiotherapy.
|Number of pages
|International journal of radiation oncology, biology, physics
|Published - Aug 30 1994
- Early response genes
- Growth factors
- Radiation mediated transcription
- Stress response