TY - JOUR
T1 - Radiation induction of immediate early genes
T2 - Effectors of the radiation-stress response
AU - Weichselbaum, Ralph R.
AU - Hallahan, Dennis
AU - Fuks, Zvi
AU - Kufe, Donald
N1 - Funding Information:
Acknowledgements-We would like to thank ROl grants CA-42596 and CA-41068, and the Center for Radiation Therapy, and the Chicago Tumor Institute, Chicago, IL, for their support. Accepted for publication 10 March 1994.
PY - 1994/8/30
Y1 - 1994/8/30
N2 - Recent studies have demonstrated that the early response genes c-jun, Egr-1, c-fos, and NFKB are induced following exposure of mammalian cells to ionizing radiation. We propose that the products of these early response genes regulate downstream genes that are important in the adaptation of cells and tissues to radiation-induced stress. Potential downstream targets include cytokine and growth factor genes as well as deoxyribonucleic acid (DNA) repair genes. Early response gene products may also regulate cell cycle progression following cellular x-irradiation. Signal transduction pathways that allow cells to adapt to radiation may provide molecular targets to modify tumor and normal responses to radiotherapy.
AB - Recent studies have demonstrated that the early response genes c-jun, Egr-1, c-fos, and NFKB are induced following exposure of mammalian cells to ionizing radiation. We propose that the products of these early response genes regulate downstream genes that are important in the adaptation of cells and tissues to radiation-induced stress. Potential downstream targets include cytokine and growth factor genes as well as deoxyribonucleic acid (DNA) repair genes. Early response gene products may also regulate cell cycle progression following cellular x-irradiation. Signal transduction pathways that allow cells to adapt to radiation may provide molecular targets to modify tumor and normal responses to radiotherapy.
KW - Early response genes
KW - Growth factors
KW - Radiation mediated transcription
KW - Stress response
UR - http://www.scopus.com/inward/record.url?scp=0028141973&partnerID=8YFLogxK
U2 - 10.1016/0360-3016(94)90539-8
DO - 10.1016/0360-3016(94)90539-8
M3 - Article
C2 - 8083118
AN - SCOPUS:0028141973
SN - 0360-3016
VL - 30
SP - 229
EP - 234
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
IS - 1
ER -