Radiation-induced cardiac dysfunction: Practical implications

Lauren N. Pedersen, Walter Schiffer, Joshua D. Mitchell, Carmen Bergom

Research output: Contribution to journalReview articlepeer-review

Abstract

Radiation-induced cardiac dysfunction is a critical healthcare concern facing survivors of thoracic cancers treated with radiation therapy. Despite cardiac-sparing advances in radiation therapy delivery, many patients with thoracic cancers receiving modern radiation therapy will still have incidental radiation exposure to the heart. Therefore, it is imperative that cardiovascular healthcare providers take appropriate measures to prevent, screen, and manage radiation-induced cardiac dysfunction in patients with a history of thoracic radiation therapy. In this review, we aim to provide healthcare providers with foundational information about radiation-induced cardiac pathophysiology and a chronology of advances in radiation technology. Subsequently, we provide an up-to-date review of treatment- and host-related factors that can influence a patient’s risk for radiation-induced cardiac dysfunction. Finally, we culminate our discussion by detailing current screening and management guidelines to aid healthcare providers in caring for their patients with a history of thoracic radiation therapy.

Original languageEnglish
Pages (from-to)256-265
Number of pages10
JournalKardiologia Polska
Volume80
Issue number3
DOIs
StatePublished - 2022

Keywords

  • cancer
  • cardio-oncology
  • cardiovascular disease
  • radiation
  • radiation-induced cardiac dysfunction

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