Radiation Dose-Volume Effects in the Lung

Lawrence B. Marks, Soren M. Bentzen, Joseph O. Deasy, Feng Ming (Spring) Kong, Jeffrey D. Bradley, Ivan S. Vogelius, Issam El Naqa, Jessica L. Hubbs, Joos V. Lebesque, Robert D. Timmerman, Mary K. Martel, Andrew Jackson

    Research output: Contribution to journalArticlepeer-review

    727 Scopus citations


    The three-dimensional dose, volume, and outcome data for lung are reviewed in detail. The rate of symptomatic pneumonitis is related to many dosimetric parameters, and there are no evident threshold "tolerance dose-volume" levels. There are strong volume and fractionation effects.

    Original languageEnglish
    Pages (from-to)S70-S76
    JournalInternational Journal of Radiation Oncology Biology Physics
    Issue number3 SUPPL.
    StatePublished - Mar 1 2010


    • Lung injury
    • Pneumonitis
    • Radiation


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