Racial disparities and human papillomavirus status in oropharyngeal cancer: A systematic review and meta-analysis

Nicholas R. Lenze, Douglas R. Farquhar, Angela L. Mazul, Maheer M. Masood, Jose P. Zevallos

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Background: This study used a meta-analysis to quantify the degree to which the racial disparity in overall survival for black versus white Americans with oropharyngeal squamous cell carcinoma (OPSCC) persists after adjusting for human papillomavirus (HPV) status. Methods: PubMed/MEDLINE, Cochrane Database of Systematic Reviews, and CINAHLA were searched through November 2017. The PRISMA statement was followed. The pooled hazard ratio (HR) was calculated using a random-effects model. Results: Five studies met the inclusion criteria and had suitable data for pooling into the meta-analysis (N = 1153). The pooled HR for overall survival in black versus white Americans with OPSCC after adjusting for HPV status was calculated to be 1.45 (95% confidence interval, 0.87-2.40). Conclusions: The difference in survival for black versus white Americans with OPSCC is not significant after adjusting for HPV status but still trends in the direction of a disparity. Additional studies are needed to better characterize this disparity.

Original languageEnglish
Pages (from-to)256-261
Number of pages6
JournalHead and Neck
Volume41
Issue number1
DOIs
StatePublished - Jan 2019

Keywords

  • health status disparities
  • human papillomavirus
  • meta-analysis
  • oropharyngeal cancer
  • survival

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