Racial differences in genetic factors associated with breast cancer

Foluso O. Ademuyiwa, Olufunmilayo I. Olopade

Research output: Contribution to journalReview articlepeer-review

56 Scopus citations

Abstract

Breast cancer in African Americans in the US is more aggressive and has a worse outcome than breast cancer in Caucasians. Although the incidence of breast cancer among US whites is higher than among blacks, the mortality rates for blacks are much higher. Breast cancer in blacks is also associated with a more advanced stage at presentation and pathologically aggressive tumors commonly exhibiting estrogen receptor negativity, higher S-phase fractions, and higher numbers of involved lymph nodes. This paper reviews some of the genetic factors that have been shown to be associated with a difference in breast cancer outcome between African Americans and Caucasians in the US such as the BRCA1 and BRCA2 genes, p53 mutations, UGT1A1 gene polymorphisms, and HER-2/neu gene amplifications/overexpression.

Original languageEnglish
Pages (from-to)47-53
Number of pages7
JournalCancer and Metastasis Reviews
Volume22
Issue number1
DOIs
StatePublished - Mar 2003

Keywords

  • African American
  • Breast cancer
  • Caucasian
  • Genetic differences

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