TY - JOUR
T1 - Race is associated with sexual behaviors and modifies the effect of age on human papillomavirus serostatus among perimenopausal women
AU - Rettig, Eleni Marie
AU - Fakhry, Carole
AU - Rositch, Anne F.
AU - Burke, Anne E.
AU - Chang, Kathryn
AU - Silver, Michelle I.
AU - Viscidi, Raphael
AU - Gravitt, Patti
N1 - Funding Information:
The authors thank Yolanda Eby, Roslyn Howard, Aleksandra Ogurtsova, and Barbara Silver for laboratory testing; Lori Hackett for research administration; Emily Seay, Rebecca Redett, and Jean Murphy for study recruitment follow-up; and the clinical providers support teams at Johns Hopkins Women''s Health Center at Green Spring Station, Johns HopkinsWomen''s Services at the BayviewMedical Offices, and Johns HopkinsWomen''s Services at WhiteMarsh. Finally, the authors thank the women who generously volunteered their time as participants in the HPV in Perimenopause Cohort, for their invaluable contributions and commitment to this study. This work was supported by the National Cancer Institute of the National Institutes of Health, Grant R01 CA123467 (P.G.). The content is solely the responsibility of the authors and does not necessarily represent the official view of the National Institutes of Health.
Publisher Copyright:
© 2016 American Sexually Transmitted Diseases Association All rights reserved.
PY - 2016/3/4
Y1 - 2016/3/4
N2 - Background: Human papillomavirus (HPV) causes oropharyngeal and cervical cancers. Oropharyngeal cancer primarily affects whites, but cervical cancer is more common among blacks. Reasons for this distinct epidemiology are unclear. Methods: Serum was collected from women aged 35 to 60 years in the HPVin Perimenopause cohort and evaluated for antibodies to 8 HPV types. Demographic and behavioral data were collected by telephone questionnaire. Associations between sexual behaviors, race, age, HPV serostatus, and strength of serologic response to HPV were evaluated. Results: There were 781 women in this analysis, including 620 white (79%) and 161 (21%) black women. Whites were less likely to report 5+ vaginal sex partners (prevalence ratio [PR], 0.86; 95% confidence interval [CI], 0.77-0.97), but more likely to report 5+ oral sex partners (PR, 2.38; 95% CI, 1.62-3.49) compared with blacks. Seropositivity to most individual HPV types and at least 3 types was significantly lower in whites than in blacks (PR, 0.62; 95% CI, 0.47-0.80). Human papillomavirus seropositivity was independently associated with younger age among blacks, but with sexual exposures among whites. Furthermore, strength of serologic response to most HPV types significantly decreased with older age among blacks, but not among whites. Conclusions: Racial differences in immune markers of HPV exposure and the epidemiology of HPV-related cancers may be linked to differences in patterns of sexual behaviors.
AB - Background: Human papillomavirus (HPV) causes oropharyngeal and cervical cancers. Oropharyngeal cancer primarily affects whites, but cervical cancer is more common among blacks. Reasons for this distinct epidemiology are unclear. Methods: Serum was collected from women aged 35 to 60 years in the HPVin Perimenopause cohort and evaluated for antibodies to 8 HPV types. Demographic and behavioral data were collected by telephone questionnaire. Associations between sexual behaviors, race, age, HPV serostatus, and strength of serologic response to HPV were evaluated. Results: There were 781 women in this analysis, including 620 white (79%) and 161 (21%) black women. Whites were less likely to report 5+ vaginal sex partners (prevalence ratio [PR], 0.86; 95% confidence interval [CI], 0.77-0.97), but more likely to report 5+ oral sex partners (PR, 2.38; 95% CI, 1.62-3.49) compared with blacks. Seropositivity to most individual HPV types and at least 3 types was significantly lower in whites than in blacks (PR, 0.62; 95% CI, 0.47-0.80). Human papillomavirus seropositivity was independently associated with younger age among blacks, but with sexual exposures among whites. Furthermore, strength of serologic response to most HPV types significantly decreased with older age among blacks, but not among whites. Conclusions: Racial differences in immune markers of HPV exposure and the epidemiology of HPV-related cancers may be linked to differences in patterns of sexual behaviors.
UR - http://www.scopus.com/inward/record.url?scp=84958794179&partnerID=8YFLogxK
U2 - 10.1097/OLQ.0000000000000426
DO - 10.1097/OLQ.0000000000000426
M3 - Article
C2 - 26967299
AN - SCOPUS:84958794179
SN - 0148-5717
VL - 43
SP - 231
EP - 237
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
IS - 4
ER -