TY - JOUR
T1 - Race-based demographic, anthropometric and clinical correlates of N-terminal-pro B-type natriuretic peptide
AU - Patel, Nirav
AU - Gutiérrez, Orlando M.
AU - Arora, Garima
AU - Howard, George
AU - Howard, Virginia J.
AU - Judd, Suzanne E.
AU - Prabhu, Sumanth D.
AU - Levitan, Emily B.
AU - Cushman, Mary
AU - Arora, Pankaj
N1 - Funding Information:
We thank investigators, staff, and participants of the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study for their valuable contributions. A full list of investigators and institutions can be found at http://www.regardsstudy.org. The REGARDS research project is supported by a cooperative agreement U01 NS041588 from the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Service. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke or the National Institutes of Health. Representatives of the funding agency have been involved in the review of the manuscript but not directly involved in the collection, management, analysis or interpretation of the data. Additional support was provided by grant R01-HL080477 from the National Heart, Lung, and Blood Institute. Dr. Nirav Patel is supported by National Institutes of Health grant 5T32HL129948-02. Dr. Pankaj Arora is supported by American Heart Association Career Development Award 18CDA34110135. Dr. Levitan has received research grants from Amgen, served on Amgen advisory boards, and as a consultant for a research study funded by Novartis. None of the other authors report any significant relationships with industry or financial disclosures related to this manuscript. Dr. Gutierrez has received honoraria from Amgen and Keryx, and grant support from Amgen, Keryx and GSK.
Funding Information:
The REGARDS research project is supported by a cooperative agreement U01 NS041588 from the National Institute of Neurological Disorders and Stroke , National Institutes of Health , Department of Health and Human Service . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke or the National Institutes of Health. Representatives of the funding agency have been involved in the review of the manuscript but not directly involved in the collection, management, analysis or interpretation of the data. Additional support was provided by grant R01-HL080477 from the National Heart, Lung, and Blood Institute . Dr. Nirav Patel is supported by National Institutes of Health grant 5T32HL129948-02 . Dr. Pankaj Arora is supported by American Heart Association Career Development Award 18CDA34110135 .
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Background: Population studies have shown that black race is a natriuretic peptide (NP) deficiency state. We sought to assess whether the effects of age, sex, body mass index (BMI) and estimated glomerular filtration rate (eGFR) on N-terminal-pro-B-type NP (NT-proBNP) levels differ in white and black individuals. Methods: The study population consisted of a stratified random cohort from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. The study outcomes were the effects of age, sex, BMI and eGFR on NT-proBNP levels independent of socioeconomic and cardiovascular disease factors. Multivariable regression analyses were used to assess the effects of age, sex, BMI and eGFR on NT-proBNP levels in blacks and whites. Results: Of the 27,679 participants in the weighted sample, 54.7% were females, 40.6% were black, and the median age was 64 years. Every 10-year higher age was associated with 38% [95% confidence interval (CI): 30%–45%] and 34% (95% CI: 22%–43%) higher NT-proBNP levels in whites and blacks, respectively. Female sex was associated with 31% (95% CI: 20%–43%) higher NT-proBNP levels in whites and 28% (95% CI: 15%–45%) higher in blacks. There was a significant linear inverse relationship between BMI and NT-proBNP in whites and a non-linear inverse relationship in blacks. Whites and blacks had a non-linear inverse relationship between eGFR and NT-proBNP. However, the non-linear relationship between NT-proBNP and eGFR differed by race (p = 0.01 for interaction). Conclusions: The association of age and sex with NT-proBNP levels was similar in blacks and whites but the form of the BMI and eGFR relationship differed by race.
AB - Background: Population studies have shown that black race is a natriuretic peptide (NP) deficiency state. We sought to assess whether the effects of age, sex, body mass index (BMI) and estimated glomerular filtration rate (eGFR) on N-terminal-pro-B-type NP (NT-proBNP) levels differ in white and black individuals. Methods: The study population consisted of a stratified random cohort from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. The study outcomes were the effects of age, sex, BMI and eGFR on NT-proBNP levels independent of socioeconomic and cardiovascular disease factors. Multivariable regression analyses were used to assess the effects of age, sex, BMI and eGFR on NT-proBNP levels in blacks and whites. Results: Of the 27,679 participants in the weighted sample, 54.7% were females, 40.6% were black, and the median age was 64 years. Every 10-year higher age was associated with 38% [95% confidence interval (CI): 30%–45%] and 34% (95% CI: 22%–43%) higher NT-proBNP levels in whites and blacks, respectively. Female sex was associated with 31% (95% CI: 20%–43%) higher NT-proBNP levels in whites and 28% (95% CI: 15%–45%) higher in blacks. There was a significant linear inverse relationship between BMI and NT-proBNP in whites and a non-linear inverse relationship in blacks. Whites and blacks had a non-linear inverse relationship between eGFR and NT-proBNP. However, the non-linear relationship between NT-proBNP and eGFR differed by race (p = 0.01 for interaction). Conclusions: The association of age and sex with NT-proBNP levels was similar in blacks and whites but the form of the BMI and eGFR relationship differed by race.
KW - Clinical correlates
KW - NT-proBNP
KW - Race
UR - http://www.scopus.com/inward/record.url?scp=85062691031&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2019.02.034
DO - 10.1016/j.ijcard.2019.02.034
M3 - Article
C2 - 30878238
AN - SCOPUS:85062691031
SN - 0167-5273
VL - 286
SP - 145
EP - 151
JO - International Journal of Cardiology
JF - International Journal of Cardiology
ER -