TY - JOUR
T1 - Race and sex disparities in long-term survival of oral and oropharyngeal cancer in the United States
AU - Osazuwa-Peters, Nosayaba
AU - Massa, Sean T.
AU - Christopher, Kara M.
AU - Walker, Ronald J.
AU - Varvares, Mark A.
N1 - Publisher Copyright:
© 2015, Springer-Verlag Berlin Heidelberg.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Purpose: To investigate the effect of race and sex on long-term survival of oral and oropharyngeal cancer. Methods: The Surveillance, Epidemiology and End Results database was queried for adult oral and oropharyngeal cancer patients with at least 25-year follow-up. Kaplan–Meier survival curves and cox proportional hazards model were used to identify differences. Results: Of the 22,162 patients identified, 70.3 % were males. Only 8.9 % were alive at 25 years post-diagnosis. Black males show the poorest overall and disease-specific survival rates (p < 0.001). After controlling for covariates, Blacks had a 40 % higher hazard of mortality compared with Whites (HR 1.40, 95 % CI 1.35–1.46), while females had a 9 % reduction in mortality risk (HR 0.91, 95 % CI 0.88–0.94). Conclusions: Overall and disease-specific survival is poor for oral and oropharyngeal cancer patients, and Black men fare worst. This illustrates the need for long-term cancer survival plans incorporating disparity effects in overall cancer outcomes.
AB - Purpose: To investigate the effect of race and sex on long-term survival of oral and oropharyngeal cancer. Methods: The Surveillance, Epidemiology and End Results database was queried for adult oral and oropharyngeal cancer patients with at least 25-year follow-up. Kaplan–Meier survival curves and cox proportional hazards model were used to identify differences. Results: Of the 22,162 patients identified, 70.3 % were males. Only 8.9 % were alive at 25 years post-diagnosis. Black males show the poorest overall and disease-specific survival rates (p < 0.001). After controlling for covariates, Blacks had a 40 % higher hazard of mortality compared with Whites (HR 1.40, 95 % CI 1.35–1.46), while females had a 9 % reduction in mortality risk (HR 0.91, 95 % CI 0.88–0.94). Conclusions: Overall and disease-specific survival is poor for oral and oropharyngeal cancer patients, and Black men fare worst. This illustrates the need for long-term cancer survival plans incorporating disparity effects in overall cancer outcomes.
KW - Long-term survival
KW - Oral cavity cancer
KW - Oropharyngeal cancer
KW - Outcomes
KW - Racial and sex disparities
UR - http://www.scopus.com/inward/record.url?scp=84955707189&partnerID=8YFLogxK
U2 - 10.1007/s00432-015-2061-8
DO - 10.1007/s00432-015-2061-8
M3 - Article
C2 - 26507889
AN - SCOPUS:84955707189
SN - 0171-5216
VL - 142
SP - 521
EP - 528
JO - Journal of Cancer Research and Clinical Oncology
JF - Journal of Cancer Research and Clinical Oncology
IS - 2
ER -