Rac activation induces NADPH oxidase activity in transgenic COS^phox cells, and the level of superoxide production is exchange factor-dependent

Keyphrases

• Transgenic 100%
• Constitutively Active 100%
• Superoxide Production 100%
• Exchange Factor 100%
• NADPH Oxidase Activity 100%
• Rac Activation 100%
• P47phox 80%
• Rac1 60%
• P67phox 60%
• Guanine nucleotide Exchange Factor 60%
• Vav1 40%
• Oxidase 40%
• Active Form 20%
• Signaling Events 20%
• Physiologically Relevant 20%
• Complementary DNA (cDNA) 20%
• Gp91phox 20%
• Transient Expression 20%
• P22phox 20%
• NADPH Oxidase 20%
• COS-7 Cells 20%
• Phagocyte NADPH Oxidase 20%
• Effector Proteins 20%
• Rac1-GTP 20%
• Dual Role 20%
• Effector Domain 20%
• Vav2 20%
• G12V 20%
• TIAM1 20%
• Oxidase Assembly 20%
• G30S 20%

Biochemistry, Genetics and Molecular Biology

• Transgenics 100%
• NAD(P)H Oxidase 100%
• Oxidoreductase 75%
• Oxidase 75%
• Guanine Nucleotide Exchange Factor 75%
• Transgene 25%
• Guanosine Triphosphate 25%
• Phagocyte 25%
• Transient Expression 25%
• P22phox 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Superoxide 100%
• Reduced Nicotinamide Adenine Dinucleotide Phosphate Oxidase 100%
• Oxidoreductase 75%
• Guanine Nucleotide Exchange Factor 75%
• Guanosine Triphosphate 25%