TY - JOUR
T1 - R9AP and R7BP
T2 - traffic cops for the RGS7 family in phototransduction and neuronal GPCR signaling
AU - Jayaraman, Muralidharan
AU - Zhou, Hao
AU - Jia, Lixia
AU - Cain, Matthew D.
AU - Blumer, Kendall J.
N1 - Funding Information:
Research in the authors’ laboratory is supported by NIH grants GM44592 and HL0753632 and DOD grant BC060037 (awarded to K.J.B.).
PY - 2009/1
Y1 - 2009/1
N2 - RGS (regulator of G protein signaling) proteins have emerged as crucial regulators, effectors and integrators in G-protein-coupled receptor (GPCR) signaling networks. Many RGS proteins accelerate GTP hydrolysis by Gα subunits, thereby regulating G protein activity, whereas certain RGS proteins also transduce Gα signals to downstream targets. Particularly intriguing are members of the RGS7 (R7) family (RGS6, RGS7, RGS9 and RGS11), which heterodimerize with Gβ5. In Caenorhabditis elegans, R7-Gβ5 heterodimers regulate synaptic transmission, anesthetic action and behavior. In vertebrates, they regulate vision, postnatal development, working memory and the action of psychostimulants or morphine. Here we highlight R9AP and R7BP, a related pair of recently identified SNARE-like R7-family binding proteins, which regulate intracellular trafficking, expression and function of R7-Gβ5 heterodimers in retina and brain. Emerging understanding of R7BP and R9AP promises to provide new insights into neuronal GPCR signaling mechanisms relevant to the causes and treatment of neurological disorders.
AB - RGS (regulator of G protein signaling) proteins have emerged as crucial regulators, effectors and integrators in G-protein-coupled receptor (GPCR) signaling networks. Many RGS proteins accelerate GTP hydrolysis by Gα subunits, thereby regulating G protein activity, whereas certain RGS proteins also transduce Gα signals to downstream targets. Particularly intriguing are members of the RGS7 (R7) family (RGS6, RGS7, RGS9 and RGS11), which heterodimerize with Gβ5. In Caenorhabditis elegans, R7-Gβ5 heterodimers regulate synaptic transmission, anesthetic action and behavior. In vertebrates, they regulate vision, postnatal development, working memory and the action of psychostimulants or morphine. Here we highlight R9AP and R7BP, a related pair of recently identified SNARE-like R7-family binding proteins, which regulate intracellular trafficking, expression and function of R7-Gβ5 heterodimers in retina and brain. Emerging understanding of R7BP and R9AP promises to provide new insights into neuronal GPCR signaling mechanisms relevant to the causes and treatment of neurological disorders.
UR - http://www.scopus.com/inward/record.url?scp=58149129117&partnerID=8YFLogxK
U2 - 10.1016/j.tips.2008.10.002
DO - 10.1016/j.tips.2008.10.002
M3 - Review article
C2 - 19042037
AN - SCOPUS:58149129117
VL - 30
SP - 17
EP - 24
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
SN - 0165-6147
IS - 1
ER -