R spider: A network-based analysis of gene lists by combining signaling and metabolic pathways from Reactome and KEGG databases

Alexey V. Antonov; Esther E. Schmidt; Sabine Dietmann; Maria Krestyaninova; Henning Hermjakob

doi:10.1093/nar/gkq482

R spider: A network-based analysis of gene lists by combining signaling and metabolic pathways from Reactome and KEGG databases

Alexey V. Antonov, Esther E. Schmidt, Sabine Dietmann, Maria Krestyaninova, Henning Hermjakob

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

R spider is a web-based tool for the analysis of a gene list using the systematic knowledge of core pathways and reactions in human biology accumulated in the Reactome and KEGG databases. R spider implements a network-based statistical framework, which provides a global understanding of gene relations in the supplied gene list, and fully exploits the Reactome and KEGG knowledge bases. R spider provides a user-friendly dialog-driven web interface for several model organisms and supports most available gene identifiers. R spider is freely available at http://mips.helmholtz-muenchen.de/proj/rspider.

Original language	English
Article number	gkq482
Pages (from-to)	W78-W83
Journal	Nucleic acids research
Volume	38
Issue number	SUPPL. 2
DOIs	https://doi.org/10.1093/nar/gkq482
State	Published - Jun 2 2010

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abstract = "R spider is a web-based tool for the analysis of a gene list using the systematic knowledge of core pathways and reactions in human biology accumulated in the Reactome and KEGG databases. R spider implements a network-based statistical framework, which provides a global understanding of gene relations in the supplied gene list, and fully exploits the Reactome and KEGG knowledge bases. R spider provides a user-friendly dialog-driven web interface for several model organisms and supports most available gene identifiers. R spider is freely available at http://mips.helmholtz-muenchen.de/proj/rspider.",

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AU - Schmidt, Esther E.

AU - Dietmann, Sabine

AU - Krestyaninova, Maria

AU - Hermjakob, Henning

N1 - Funding Information: Funding for open access charge: European Bioinformatics Institute, Wellcome Trust Genome Campus; The development of Reactome is supported by a grant from the US National Institutes of Health (P41 HG003751) and EU grant LSHG-CT-2005-518254 ‘‘ENFIN’’.

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R spider: A network-based analysis of gene lists by combining signaling and metabolic pathways from Reactome and KEGG databases

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