R spider: A network-based analysis of gene lists by combining signaling and metabolic pathways from Reactome and KEGG databases

Alexey V. Antonov, Esther E. Schmidt, Sabine Dietmann, Maria Krestyaninova, Henning Hermjakob

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

R spider is a web-based tool for the analysis of a gene list using the systematic knowledge of core pathways and reactions in human biology accumulated in the Reactome and KEGG databases. R spider implements a network-based statistical framework, which provides a global understanding of gene relations in the supplied gene list, and fully exploits the Reactome and KEGG knowledge bases. R spider provides a user-friendly dialog-driven web interface for several model organisms and supports most available gene identifiers. R spider is freely available at http://mips.helmholtz-muenchen.de/proj/rspider.

Original languageEnglish
Article numbergkq482
Pages (from-to)W78-W83
JournalNucleic acids research
Volume38
Issue numberSUPPL. 2
DOIs
StatePublished - Jun 2 2010

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