Quisqualate and N-methyl-d-aspartate (NMDA) receptors in induction of hippocampal long-term facilitation using conditioning solution

Yukitoshi Izumi, Hiroyoshi Miyakawa, Ken ichi Ito, Hiroshi Kato

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Brief electrical high-frequency stimulation (tetanus) via the synapses induces long-term potentiation (LTP) in hippocampal neurons. In order to elucidate how LTP is produced, we attempted to induce long-term facilitation (LTF) by perfusing a conditioning solution (CS) instead of the tetanus. A 5 min perfusion of hippocampal slices with a CS containing glutamate, K+ at high concentration and no Mg2+ resulted in the generation of LTF in CA1 and dentate neurons. CS lacking one of these 3 factors failed to produce LTF. When the glutamate of the CS was substituted by both quisqualate and N-methyl-d-aspartate (NMDA), LTF was initiated. This indicates that both quisqualate and NMDA receptors play an important role in the induction of LTP.

Original languageEnglish
Pages (from-to)201-206
Number of pages6
JournalNeuroscience Letters
Volume83
Issue number1-2
DOIs
StatePublished - Dec 16 1987
Externally publishedYes

Keywords

  • Glutamate
  • Hippocampal slice
  • Long-term potentiation
  • N-Methyl-d-aspartate (NMDA)
  • Potassium
  • Quisqualate

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