Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis

Joanna Kalucka; Laura Bierhansl; Nadine Vasconcelos Conchinha; Rindert Missiaen; Ilaria Elia; Ulrike Brüning; Samantha Scheinok; Lucas Treps; Anna Rita Cantelmo; Charlotte Dubois; Pauline de Zeeuw; Jermaine Goveia; Annalisa Zecchin; Federico Taverna; Francisco Morales-Rodriguez; Aleksandra Brajic; Lena Christin Conradi; Sandra Schoors; Ulrike Harjes; Kim Vriens; Gregor Alexander Pilz; Rongyuan Chen; Richard Cubbon; Bernard Thienpont; Bert Cruys; Brian W. Wong; Bart Ghesquière; Mieke Dewerchin; Katrien De Bock; Xavier Sagaert; Sebastian Jessberger; Elizabeth A.V. Jones; Bernard Gallez; Diether Lambrechts; Massimiliano Mazzone; Guy Eelen; Xuri Li; Sarah Maria Fendt; Peter Carmeliet

doi:10.1016/j.cmet.2018.07.016

Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis

Joanna Kalucka, Laura Bierhansl, Nadine Vasconcelos Conchinha, Rindert Missiaen, Ilaria Elia, Ulrike Brüning, Samantha Scheinok, Lucas Treps, Anna Rita Cantelmo, Charlotte Dubois, Pauline de Zeeuw, Jermaine Goveia, Annalisa Zecchin, Federico Taverna, Francisco Morales-Rodriguez, Aleksandra Brajic, Lena Christin Conradi, Sandra Schoors, Ulrike Harjes, Kim VriensGregor Alexander Pilz, Rongyuan Chen, Richard Cubbon, Bernard Thienpont, Bert Cruys, Brian W. Wong, Bart Ghesquière, Mieke Dewerchin, Katrien De Bock, Xavier Sagaert, Sebastian Jessberger, Elizabeth A.V. Jones, Bernard Gallez, Diether Lambrechts, Massimiliano Mazzone, Guy Eelen, Xuri Li, Sarah Maria Fendt, Peter Carmeliet

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171 Scopus citations

Abstract

Kalucka et al. show that fatty acid β-oxidation in quiescent endothelial cells (QECs) is indispensable to maintain redox balance and prevent EC dysfunction. In contrast to proliferating ECs (PECs), QECs reprogram their metabolism to increase regeneration of NAPDH, which is then used by vasculoprotective (NADPH-consuming) enzymes for redox homeostasis.

Original language	English
Pages (from-to)	881-894.e13
Journal	Cell metabolism
Volume	28
Issue number	6
DOIs	https://doi.org/10.1016/j.cmet.2018.07.016
State	Published - Dec 4 2018

Keywords

CPT1A
angiogenesis
endothelial cell dysfunction
endothelial cells
fatty acid β-oxidation
metabolism
quiescence
redox homeostasis

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10.1016/j.cmet.2018.07.016

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Kalucka, J., Bierhansl, L., Conchinha, N. V., Missiaen, R., Elia, I., Brüning, U., Scheinok, S., Treps, L., Cantelmo, A. R., Dubois, C., de Zeeuw, P., Goveia, J., Zecchin, A., Taverna, F., Morales-Rodriguez, F., Brajic, A., Conradi, L. C., Schoors, S., Harjes, U., ... Carmeliet, P. (2018). Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis. Cell metabolism, 28(6), 881-894.e13. https://doi.org/10.1016/j.cmet.2018.07.016

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title = "Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis",

abstract = "Kalucka et al. show that fatty acid β-oxidation in quiescent endothelial cells (QECs) is indispensable to maintain redox balance and prevent EC dysfunction. In contrast to proliferating ECs (PECs), QECs reprogram their metabolism to increase regeneration of NAPDH, which is then used by vasculoprotective (NADPH-consuming) enzymes for redox homeostasis.",

keywords = "CPT1A, angiogenesis, endothelial cell dysfunction, endothelial cells, fatty acid β-oxidation, metabolism, quiescence, redox homeostasis",

author = "Joanna Kalucka and Laura Bierhansl and Conchinha, {Nadine Vasconcelos} and Rindert Missiaen and Ilaria Elia and Ulrike Br{\"u}ning and Samantha Scheinok and Lucas Treps and Cantelmo, {Anna Rita} and Charlotte Dubois and {de Zeeuw}, Pauline and Jermaine Goveia and Annalisa Zecchin and Federico Taverna and Francisco Morales-Rodriguez and Aleksandra Brajic and Conradi, {Lena Christin} and Sandra Schoors and Ulrike Harjes and Kim Vriens and Pilz, {Gregor Alexander} and Rongyuan Chen and Richard Cubbon and Bernard Thienpont and Bert Cruys and Wong, {Brian W.} and Bart Ghesqui{\`e}re and Mieke Dewerchin and {De Bock}, Katrien and Xavier Sagaert and Sebastian Jessberger and Jones, {Elizabeth A.V.} and Bernard Gallez and Diether Lambrechts and Massimiliano Mazzone and Guy Eelen and Xuri Li and Fendt, {Sarah Maria} and Peter Carmeliet",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = dec,

day = "4",

doi = "10.1016/j.cmet.2018.07.016",

language = "English",

volume = "28",

pages = "881--894.e13",

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Kalucka, J, Bierhansl, L, Conchinha, NV, Missiaen, R, Elia, I, Brüning, U, Scheinok, S, Treps, L, Cantelmo, AR, Dubois, C, de Zeeuw, P, Goveia, J, Zecchin, A, Taverna, F, Morales-Rodriguez, F, Brajic, A, Conradi, LC, Schoors, S, Harjes, U, Vriens, K, Pilz, GA, Chen, R, Cubbon, R, Thienpont, B, Cruys, B, Wong, BW, Ghesquière, B, Dewerchin, M, De Bock, K, Sagaert, X, Jessberger, S, Jones, EAV, Gallez, B, Lambrechts, D, Mazzone, M, Eelen, G, Li, X, Fendt, SM & Carmeliet, P 2018, 'Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis', Cell metabolism, vol. 28, no. 6, pp. 881-894.e13. https://doi.org/10.1016/j.cmet.2018.07.016

TY - JOUR

T1 - Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis

AU - Kalucka, Joanna

AU - Bierhansl, Laura

AU - Conchinha, Nadine Vasconcelos

AU - Missiaen, Rindert

AU - Elia, Ilaria

AU - Brüning, Ulrike

AU - Scheinok, Samantha

AU - Treps, Lucas

AU - Cantelmo, Anna Rita

AU - Dubois, Charlotte

AU - de Zeeuw, Pauline

AU - Goveia, Jermaine

AU - Zecchin, Annalisa

AU - Taverna, Federico

AU - Morales-Rodriguez, Francisco

AU - Brajic, Aleksandra

AU - Conradi, Lena Christin

AU - Schoors, Sandra

AU - Harjes, Ulrike

AU - Vriens, Kim

AU - Pilz, Gregor Alexander

AU - Chen, Rongyuan

AU - Cubbon, Richard

AU - Thienpont, Bernard

AU - Cruys, Bert

AU - Wong, Brian W.

AU - Ghesquière, Bart

AU - Dewerchin, Mieke

AU - De Bock, Katrien

AU - Sagaert, Xavier

AU - Jessberger, Sebastian

AU - Jones, Elizabeth A.V.

AU - Gallez, Bernard

AU - Lambrechts, Diether

AU - Mazzone, Massimiliano

AU - Eelen, Guy

AU - Li, Xuri

AU - Fendt, Sarah Maria

AU - Carmeliet, Peter

PY - 2018/12/4

Y1 - 2018/12/4

N2 - Kalucka et al. show that fatty acid β-oxidation in quiescent endothelial cells (QECs) is indispensable to maintain redox balance and prevent EC dysfunction. In contrast to proliferating ECs (PECs), QECs reprogram their metabolism to increase regeneration of NAPDH, which is then used by vasculoprotective (NADPH-consuming) enzymes for redox homeostasis.

AB - Kalucka et al. show that fatty acid β-oxidation in quiescent endothelial cells (QECs) is indispensable to maintain redox balance and prevent EC dysfunction. In contrast to proliferating ECs (PECs), QECs reprogram their metabolism to increase regeneration of NAPDH, which is then used by vasculoprotective (NADPH-consuming) enzymes for redox homeostasis.

KW - CPT1A

KW - angiogenesis

KW - endothelial cell dysfunction

KW - endothelial cells

KW - fatty acid β-oxidation

KW - metabolism

KW - quiescence

KW - redox homeostasis

UR - http://www.scopus.com/inward/record.url?scp=85059335593&partnerID=8YFLogxK

U2 - 10.1016/j.cmet.2018.07.016

DO - 10.1016/j.cmet.2018.07.016

M3 - Article

C2 - 30146488

AN - SCOPUS:85059335593

SN - 1550-4131

VL - 28

SP - 881-894.e13

JO - Cell metabolism

JF - Cell metabolism

IS - 6

ER -

Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis

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Keywords

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