Quercetin inhibits peripheral and spinal cord nociceptive mechanisms to reduce intense acute swimming-induced muscle pain in mice

Sergio M. Borghi, Felipe A. Pinho-Ribeiro, Victor Fattori, Allan J.C. Bussmann, Josiane A. Vignoli, Doumit Camilios-Neto, Rubia Casagrande, Waldiceu A. Verri

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45 Scopus citations

Abstract

The present study aimed to evaluate the effects of the flavonoid quercetin (3,3',4',5,7-pentahydroxyflavone) in a mice model of intense acute swimming-induced muscle pain, which resembles delayed onset muscle soreness. Quercetin intraperitoneal (i.p.) treatment dose-dependently reduced muscle mechanical hyperalgesia. Quercetin inhibited myeloperoxidase (MPO) and N-acetyl-ß-D- glucosaminidase (NAG) activities, cytokine production, oxidative stress, cyclooxygenase-2 (COX-2) and gp91phox mRNA expression and muscle injury (creatinine kinase [CK] blood levels and myoblast determination protein [MyoD] mRNA expression) as well as inhibited NF?B activation and induced Nrf2 and HO- 1 mRNA expression in the soleus muscle. Beyond inhibiting those peripheral effects, quercetin also inhibited spinal cord cytokine production, oxidative stress and glial cells activation (glial fibrillary acidic protein [GFAP] and ionized calcium-binding adapter molecule 1 [Iba-1] mRNA expression). Concluding, the present data demonstrate that quercetin is a potential molecule for the treatment of muscle pain conditions related to unaccustomed exercise.

Original languageEnglish
Article numbere0162267
JournalPloS one
Volume11
Issue number9
DOIs
StatePublished - Sep 2016

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