Quercetin inhibits inflammatory bone resorption in a mouse periodontitis model

Marcelo H. Napimoga, Juliana T. Clemente-Napimoga, Cristina G. Macedo, Fabiana F. Freitas, Rafael N. Stipp, Felipe A. Pinho-Ribeiro, Rubia Casagrande, Waldiceu A. Verri

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58 Scopus citations


Periodontitis is a disease that leads to bone destruction and represents the main cause of tooth loss in adults. The development of aggressive periodontitis has been associated with increased inflammatory response that is induced by the presence of a subgingival biofilm containing Aggregatibacter actinomycetemcomitans. The flavonoid quercetin (1) is widespread in vegetables and fruits and exhibits many biological properties for possible medical and clinical applications such as its anti-inflamatory and antioxidant effects. Thus, in the present study, the properties of 1 have been evaluated in bone loss and inflammation using a mouse periodontitis model induced by A. actinomycetemcomitans infection. Subcutaneous treatment with 1 reduced A. actinomycetemcomitans-induced bone loss and IL-1β, TNF-α, IL-17, RANKL, and ICAM-1 production in the gingival tissue without affecting bacterial counts. These results demonstrated that quercetin exhibits protective effects in A. actinomycetemcomitans-induced periodontitis in mice by modulating cytokine and ICAM-1 production.

Original languageEnglish
Pages (from-to)2316-2321
Number of pages6
JournalJournal of Natural Products
Issue number12
StatePublished - Dec 27 2013


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