Quantum dot labelling of adenovirus allows highly sensitive single cell flow and imaging cytometry

Morgan R. Herod, Robert G. Pineda, Vivien Mautner, David Onion

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

A quantum dot method for highly efficient labelling of single adenoviral particles is developed. The technique has no impact on viral fitness and allows the imaging and tracking of virus binding and internalisation events using a variety of techniques including imaging cytometry and confocal microscopy. The method is applied to characterise the tropism of different adenoviral vectors.

Original languageEnglish
Pages (from-to)797-803
Number of pages7
JournalSmall
Volume11
Issue number7
DOIs
StatePublished - Feb 18 2015
Externally publishedYes

Keywords

  • Adenovirus
  • Flow cytometry
  • Gene therapy
  • Imaging cytometry
  • Quantum dots

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