Quantitative Visual Field and Optic Disc Correlates Early in Glaucoma

A retrospective study was made of persons with ocular hypertension and normal initial visual fields. Seventy eyes were followed, and glaucomatous visual field defects developed in 25 of these eyes. In eyes with ocular hypertension, the area enclosed by the central visual field isopter (I₂e) was significantly smaller than that previously reported for an agecorrected group of eyes with normal intraocular pressure. In the absence of glaucomatous visual field defects, isopter areas were not related to cup-disc ratios. Coincident with visual field loss, reductions in both peripheral (I₄e) and central (I₂e) isopter areas correlated linearly with increases in the cup-disc ratio. Prior to visual field loss, the I₄e isopter area was significantly smaller among those eyes destined to lose visual field.