@article{26db3c6e2196443895dd785c3792279e,
title = "Quantitative trait loci analysis of human event-related brain potentials: P3 voltage",
abstract = "The P3 event-related brain potential (ERP) is a positive-going voltage change of scalp-recorded electroencephalographic activity that occurs between 300-500 ms after stimulus onset. It is elicited when a stimulus is perceived, memory operations are engaged, and attentional resources are allocated toward its processing. Because this ERP component reflects fundamental cognitive processing, it has found wide utility as an assessment of human mental function in basic and clinical studies. In particular, P3 attributes are heritable and have demonstrated considerable promise as a means to identify individuals at genetic risk for alcoholism. We have conducted a quantitative linkage analysis on a large sample from families with a high density of affected individuals. The analyses suggest that several regions of the human genome contain genetic loci related to the generation of the P3 component of the ERP, which are possible candidate loci underlying the functional organization of human neuroelectric activity.",
keywords = "Alcoholism, Event-related brain potentials, Heredity, P3, Quantitative trait loci",
author = "H. Begleiter and B. Porjesz and T. Reich and Edenberg, {H. J.} and A. Goate and J. Blangero and L. Almasy and T. Foroud and {Van Eerdewegh}, P. and J. Polich and J. Rohrbaugh and S. Kuperman and Bauer, {L. O.} and O'Connor, {S. J.} and Chorlian, {D. B.} and Li, {T. K.} and Conneally, {P. M.} and V. Hesselbrock and Rice, {J. P.} and Schuckit, {M. A.} and R. Cloninger and J. Nurnberger and R. Crowe and Bloom, {F. E.}",
note = "Funding Information: The Collaborative Study on the Genetics of Alcoholism (H. Begleiter, SUNY Health Science Center at Brooklyn, Principal Investigator: T. Reich, Washington University, Co-Principal Investigator) includes 6 different centers where data collection takes place. The 6 sites and principal investigator and co-investigators are: Indiana University (J. Nurnberger Jr., P.M. Conneally); University of Iowa (R. Crowe, S. Kuperman); University of California at San Diago and The Scripps Research Institute (M. Schuckit, F. Bloom); University of Connecticut (V. Hesselbrock); State University of New York, Health Science Center at Brooklyn (B. Porjesz, H. Begleiter); Washington University in St. Louis (T. Reich, C.R. Cloninger). We thank Arthur T. Stimus, Vladimir Kotlyarevsky, Sergio Valentini, Elisabeth Iskander, William Wu, Shantia Shears, Tom Dyer, Frank Bibbins, Kristie Carr, Candace Crose, Lynnette Helton, Susan Kelley, Dr. Maris Kowalczuk, Brenda Leake, Jennifer Reynolds, Chris Willig, Dr. Bo Wu, Jinghua Zhou, Siguna Leelasathaporn, and Pak Sirkpulkaw for their valuable technical assistance. Alison Goate is supported by a Career Development Award (AG00634). Laura Almasy is supported by NRSA (NIH GM18897). The work was supported by US NIH Grants AA08401 and AA08403. ",
year = "1998",
month = apr,
doi = "10.1016/S0168-5597(98)00002-1",
language = "English",
volume = "108",
pages = "244--250",
journal = "Electroencephalography and Clinical Neurophysiology - Evoked Potentials",
issn = "0168-5597",
number = "3",
}