TY - GEN
T1 - Quantitative small animal fluorescence tomography using an ultra-fast gated image intensifier
AU - Patwardhan, Sachin V.
AU - Bloch, Sharon
AU - Achilefu, Samuel
AU - Culver, Joseph P.
PY - 2006
Y1 - 2006
N2 - Optical approaches to small animal In vivo molecular Imaging provide high sensitivity, stable non-radioactive probes, and an extensive array of functional reporting strategies. However, quantitative whole body assays remain illusive. The quantitative accuracy of optical imaging is affected by the depth of the buried target and the heterogeneity of tissue optical properties. Tomography approaches, to obtaining in-vivo optical property maps, and whole body distributions of fluorescing probes, provide a strategy for improving the quality and quantitative accuracy of small animal optical imaging. Here we present a time-resolved, charged coupled device (CCD) based system for quantitative small animal fluorescence tomography.
AB - Optical approaches to small animal In vivo molecular Imaging provide high sensitivity, stable non-radioactive probes, and an extensive array of functional reporting strategies. However, quantitative whole body assays remain illusive. The quantitative accuracy of optical imaging is affected by the depth of the buried target and the heterogeneity of tissue optical properties. Tomography approaches, to obtaining in-vivo optical property maps, and whole body distributions of fluorescing probes, provide a strategy for improving the quality and quantitative accuracy of small animal optical imaging. Here we present a time-resolved, charged coupled device (CCD) based system for quantitative small animal fluorescence tomography.
UR - http://www.scopus.com/inward/record.url?scp=34047170471&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2006.259942
DO - 10.1109/IEMBS.2006.259942
M3 - Conference contribution
C2 - 17946130
AN - SCOPUS:34047170471
SN - 1424400325
SN - 9781424400324
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 2675
EP - 2678
BT - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
T2 - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Y2 - 30 August 2006 through 3 September 2006
ER -