Quantitative Real-Time Imaging of Myocardium Based on Ultrasonic Integrated Backscatter

Lewis J. Thomas, Benico Barzilai, Julio E. Perez, Burton E. Sobel, Samuel A. Wickline, James G. Miller

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Improved diagnosis of pathological alterations in cardiac muscle appears feasible with the use of quantitative ultrasonic imaging. Results of previous investigations indicate that discrimination between normal and ischemic myocardium can be achieved based on evaluation of integrated backscatter, defined as the frequency average of the backscatter transfer function over the useful bandwidth. In the system reported here, integrated backscatter was obtained along each radio-frequency A-line in real time. The conventional video processor in a commercial two-dimensional (2-D) echocardiographic imager was replaced by a new integrated backscatter processor, permitting acquisition in real-time of two-dimensional echocardiographic sector images of quantitative backscatter. Imaging through the intact chests of dogs with three-year-old scar from myocardial infarcts demonstrated elevated (9.5 ± 0.6 dB) time-averaged integrated backscatter and reduced magnitude of cyclic variation of backscatter (3.8 ± 0.6 dB to 0.8 ± 0.3 dB) in zones of scar compared with nonischemic zones. The observed changes in time-averaged integrated backscatter and in the magnitude of cyclic variation are consistent with the limited results that could be obtained previously without the benefit of real-time imaging.

Original languageEnglish
Pages (from-to)466-470
Number of pages5
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Issue number4
StatePublished - Jul 1989


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