Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction

Thomas C. Hanff; Jordana B. Cohen; Lei Zhao; Ali Javaheri; Payman Zamani; Stuart B. Prenner; Ernst Rietzschel; Yi Jia; Alice Walsh; Joseph Maranville; Zhaoqing Wang; Leonard Adam; Francisco Ramirez-Valle; Peter Schafer; Dietmar Seiffert; David A. Gordon; Mary E. Cvijic; Thomas P. Cappola; Julio A. Chirinos

doi:10.1016/j.jacbts.2020.11.011

Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction

Thomas C. Hanff, Jordana B. Cohen, Lei Zhao, Ali Javaheri, Payman Zamani, Stuart B. Prenner, Ernst Rietzschel, Yi Jia, Alice Walsh, Joseph Maranville, Zhaoqing Wang, Leonard Adam, Francisco Ramirez-Valle, Peter Schafer, Dietmar Seiffert, David A. Gordon, Mary E. Cvijic, Thomas P. Cappola, Julio A. Chirinos

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21 Scopus citations

Abstract

Diabetes mellitus (DM) is associated with a higher risk of heart failure hospitalization and mortality in patients with heart failure with preserved ejection fraction (HFpEF). Using SomaScan assays and proteomics analysis of plasma from participants in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) trial and the Penn Heart Failure Study, this study identified 10 proteins with significantly different expression in patients with HFpEF and DM. Of these, apolipoprotein M was found to mediate 72% (95% CI: 36% to 100%; p < 0.001) of the association between DM and the risk of cardiovascular death, aborted cardiac arrest, and heart failure hospitalization.

Original language	English
Pages (from-to)	89-99
Number of pages	11
Journal	JACC: Basic to Translational Science
Volume	6
Issue number	2
DOIs	https://doi.org/10.1016/j.jacbts.2020.11.011
State	Published - Feb 2021

Keywords

apolipoprotein M
diabetes
heart failure
mediation analysis
proteomics

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10.1016/j.jacbts.2020.11.011

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Hanff, T. C., Cohen, J. B., Zhao, L., Javaheri, A., Zamani, P., Prenner, S. B., Rietzschel, E., Jia, Y., Walsh, A., Maranville, J., Wang, Z., Adam, L., Ramirez-Valle, F., Schafer, P., Seiffert, D., Gordon, D. A., Cvijic, M. E., Cappola, T. P., & Chirinos, J. A. (2021). Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction. JACC: Basic to Translational Science, 6(2), 89-99. https://doi.org/10.1016/j.jacbts.2020.11.011

@article{c23ae4ad5a86482c97a0eadfdd08a4eb,

title = "Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction",

abstract = "Diabetes mellitus (DM) is associated with a higher risk of heart failure hospitalization and mortality in patients with heart failure with preserved ejection fraction (HFpEF). Using SomaScan assays and proteomics analysis of plasma from participants in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) trial and the Penn Heart Failure Study, this study identified 10 proteins with significantly different expression in patients with HFpEF and DM. Of these, apolipoprotein M was found to mediate 72% (95% CI: 36% to 100%; p < 0.001) of the association between DM and the risk of cardiovascular death, aborted cardiac arrest, and heart failure hospitalization.",

keywords = "apolipoprotein M, diabetes, heart failure, mediation analysis, proteomics",

author = "Hanff, {Thomas C.} and Cohen, {Jordana B.} and Lei Zhao and Ali Javaheri and Payman Zamani and Prenner, {Stuart B.} and Ernst Rietzschel and Yi Jia and Alice Walsh and Joseph Maranville and Zhaoqing Wang and Leonard Adam and Francisco Ramirez-Valle and Peter Schafer and Dietmar Seiffert and Gordon, {David A.} and Cvijic, {Mary E.} and Cappola, {Thomas P.} and Chirinos, {Julio A.}",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2021",

month = feb,

doi = "10.1016/j.jacbts.2020.11.011",

language = "English",

volume = "6",

pages = "89--99",

journal = "JACC: Basic to Translational Science",

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Hanff, TC, Cohen, JB, Zhao, L, Javaheri, A, Zamani, P, Prenner, SB, Rietzschel, E, Jia, Y, Walsh, A, Maranville, J, Wang, Z, Adam, L, Ramirez-Valle, F, Schafer, P, Seiffert, D, Gordon, DA, Cvijic, ME, Cappola, TP & Chirinos, JA 2021, 'Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction', JACC: Basic to Translational Science, vol. 6, no. 2, pp. 89-99. https://doi.org/10.1016/j.jacbts.2020.11.011

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T1 - Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction

AU - Hanff, Thomas C.

AU - Cohen, Jordana B.

AU - Zhao, Lei

AU - Javaheri, Ali

AU - Zamani, Payman

AU - Prenner, Stuart B.

AU - Rietzschel, Ernst

AU - Jia, Yi

AU - Walsh, Alice

AU - Maranville, Joseph

AU - Wang, Zhaoqing

AU - Adam, Leonard

AU - Ramirez-Valle, Francisco

AU - Schafer, Peter

AU - Seiffert, Dietmar

AU - Gordon, David A.

AU - Cvijic, Mary E.

AU - Cappola, Thomas P.

AU - Chirinos, Julio A.

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AB - Diabetes mellitus (DM) is associated with a higher risk of heart failure hospitalization and mortality in patients with heart failure with preserved ejection fraction (HFpEF). Using SomaScan assays and proteomics analysis of plasma from participants in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) trial and the Penn Heart Failure Study, this study identified 10 proteins with significantly different expression in patients with HFpEF and DM. Of these, apolipoprotein M was found to mediate 72% (95% CI: 36% to 100%; p < 0.001) of the association between DM and the risk of cardiovascular death, aborted cardiac arrest, and heart failure hospitalization.

KW - apolipoprotein M

KW - diabetes

KW - heart failure

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Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction

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