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Quantitative Phosphocreatine Mapping with a Transformer-Based Regression Network

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Phosphocreatine (PCr) is the key element of buffering adenosine triphosphate (ATP) concentration for sustaining the high energy demand of cardiomyocytes, thus maintaining normal mechanical function. CEST MRI has been employed to capture potential changes in myocardial PCr. A quantitative PCr network (QPCrNet) has been developed to provide accurate and fast PCr maps for the assessment of cardiac energy metabolism. In the simulation study, QPCrNet showed superior accuracy (lowest mean absolute error) in predicting PCr concentration and exchange rate from PCr pool to water pool. The transfer learning of QPCrNet on a canine stenosis model further proved the network capability of predicting regional difference between the diseased and remote areas and accurately predicted PCr reductions from the resting state to Dobutamine-induced stress.

Original languageEnglish
Title of host publicationProceedings - 25th IEEE International Conference on Data Mining Workshops, ICDMW 2025
PublisherIEEE Computer Society
Pages2015-2019
Number of pages5
ISBN (Electronic)9798331581329
DOIs
StatePublished - 2025
Event25th IEEE International Conference on Data Mining Workshops, ICDMW 2025 - Washington, United States
Duration: Nov 12 2025Nov 15 2025

Publication series

NameIEEE International Conference on Data Mining Workshops, ICDMW
ISSN (Print)2375-9232
ISSN (Electronic)2375-9259

Conference

Conference25th IEEE International Conference on Data Mining Workshops, ICDMW 2025
Country/TerritoryUnited States
CityWashington
Period11/12/2511/15/25

Keywords

  • CEST
  • MRI
  • PCr
  • QPCrNet

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