Quantitative multispectral ex vivo optical evaluation of human ovarian tissue using spatial frequency domain imaging

Sreyankar Nandy, Ian S. Hagemann, Matthew A. Powell, Cary Siegel, Quing Zhu

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

About 85-90% of all ovarian cancers are carcinomas; these manifest clinically as mass-forming epithelial proliferations involving the ovary. In this study, a visible light spatial frequency domain imaging (SFDI) system was used for multispectral ex vivo imaging and quantitative evaluation of freshly excised benign and malignant human ovarian tissues. A total of 14 ovaries from 11 patients undergoing oophorectomy were investigated. Using a logistic regression model with seven significant spectral and spatial features extracted from SFDI images, a sensitivity of 94.06% and specificity of 93.53% were achieved for prediction of histologically confirmed invasive carcinoma.

Original languageEnglish
Article number#325365
Pages (from-to)2451-2456
Number of pages6
JournalBiomedical Optics Express
Volume9
Issue number5
DOIs
StatePublished - May 1 2018

Keywords

  • Medical optics and biotechnology
  • ObGyn
  • Tissue characterization

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