Quantitative MRI of diffuse liver disease: Current applications and future directions

William A. Curtis, Tyler J. Fraum, Hongyu An, Yasheng Chen, Anup S. Shetty, Kathryn J. Fowler

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

As radiologic technology advances, quantitative imaging is becoming more prevalent in clinical practice. This article reviews quantitative hepatic MRI, specifically involving fat and iron deposition, by demonstrating how they were iteratively improved. These iterative improvements involved incorporating more knowledge about the physiology of liver disease and MRI physics to reduce the adverse effects caused by confounding factors. The relevant foundations of MRI physics and liver pathophysiology are briefly reviewed, followed by the various improvements made by expanding on this foundational knowledge. Results from the literature are then discussed within this context, validating the improvement of these resultant methods into clinically robust and useful techniques. Fibrosis quantification, which has been more difficult to robustly perform in clinical practice, is similarly reviewed in an online appendix, with proposals for future multiparametric directions to improve performance on the basis of the insights gained from fat and iron quantification in the liver.

Original languageEnglish
Pages (from-to)23-30
Number of pages8
JournalRadiology
Volume290
Issue number1
DOIs
StatePublished - Jan 2019

Fingerprint Dive into the research topics of 'Quantitative MRI of diffuse liver disease: Current applications and future directions'. Together they form a unique fingerprint.

Cite this